Transcription factors vs nucleosomes: Regulation of the PH05 promoter in yeast

被引：146

作者：

Svaren, J ^{[1
]}

Horz, W ^{[1
]}

机构：

[1] UNIV MUNICH,INST PHYSIOL CHEM,D-80336 MUNICH,GERMANY

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1997年 / 22卷 / 03期

关键词：

D O I：

10.1016/S0968-0004(97)01001-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Activation of the Saccharomyces cerevisiae PHO5 gene is accompanied by the disruption of four positioned nucleosomes at the promoter. The chromatin transition requires a DNA-binding protein, Pho4, and its transactivation domain. The mechanism of nucleosome disruption and the contribution of the nucleosomes to PHO5 regulation are reviewed.

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页码：93 / 97

页数：5

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