The somatotropic axis and aging: Mechanisms and persistent questions about practical implications

被引：22

作者：

Bartke, Andrzej ^{[1
,2
]}

机构：

[1] So Illinois Univ, Sch Med, Dept Internal Med, Springfield, IL 62794 USA

[2] So Illinois Univ, Sch Med, Dept Physiol, Springfield, IL 62794 USA

来源：

EXPERIMENTAL GERONTOLOGY | 2009年 / 44卷 / 6-7期

关键词：

GH; IGF-1; Aging; Frailty; Mutants; FACTOR-I IGF-1; GROWTH-HORMONE DEFICIENCY; AMES DWARF MICE; 60 YEARS OLD; LIFE-SPAN; LONGEVITY; INSULIN; ADULTS; HUMANS; RESTRICTION;

D O I：

10.1016/j.exger.2009.04.001

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Reduced somatotropic (GH/IGF-1) signaling delays aging and extends longevity in laboratory mice. However, it is unclear whether the physiological decrease of GH and IGF-1 levels with age represents a symptom of declining neuroendocrine function, a cause of age-related alterations in body composition and functionality or a protective mechanism against age-associated disease. Although available clinical evidence does not support the use of recombinant GH as an anti-aging therapy, many studies suggest the potential utility of GH and GH secretagogues in the treatment of sarcopenia and frailty. (C) 2009 Published by Elsevier Inc.

引用

页码：372 / 374

页数：3

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