Community-associated meticillin-resistant Staphylococcus aureus: epidemiology, microbiology and clinical impact in East Yorkshire, UK

被引：12

作者：

Elston, J. W. T. ^{[1
]}

Meigh, J. ^{[2
]}

Kearns, A. M. ^{[3
]}

Jordan-Owers, N. ^{[2
]}

Newton, A. ^{[4
]}

Meigh, R. E. ^{[2
]}

Barlow, G.

机构：

[1] Castle Hill Hosp, Dept Infect & Trop Med, SpR Infect Dis, Cottingham HU16 5JQ, East Yorkshire, England

[2] Hull Royal Infirm, Dept Microbiol, Kingston Upon Hull HU3 2JZ, N Humberside, England

[3] Hlth Protect Agcy, Staphylococcus Reference Unit, Ctr Infect, London, England

[4] Humber Hlth Protect Unit, Willerby, East Yorkshire, England

来源：

JOURNAL OF HOSPITAL INFECTION | 2009年 / 72卷 / 04期

关键词：

Clinical impact; Community-associated; Epidemiology; Meticillin-resistant Staphylococcus aureus; Panton-Valentine leucocidin; VALENTINE LEUKOCIDIN GENES; SOFT-TISSUE INFECTIONS; NOSOCOMIAL TRANSMISSION; EMERGENCY-DEPARTMENT; EMERGING THREAT; MRSA; BACTEREMIA; DISEASE; SKIN;

D O I：

10.1016/j.jhin.2009.05.001

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

100235 [预防医学];

摘要：

The prevalence of community-associated meticillin-resistant Staphylococcus aureus (CA-MRSA) is increasing worldwide. Whilst CA-MRSA has been reported in the UK, there is little information concerning its clinical impact. Here we report three epidemic lineages of CA-MRSA occurring in East Yorkshire and describe their epidemiology, microbiology and clinical impact. Although CA-MRSA was most often associated with uncomplicated skin and soft tissue infections or asymptomatic colonisation, serious infection and fatalities were documented. Community-based transmission was noted in two separate households. We highlight limitations to existing definitions and propose debate to further define CA-MRSA and allow further study of its epidemiology and clinical impact in the UK. (C) 2009 The Hospital Infection Society. Published by Elsevier Ltd. All rights reserved.

引用

页码：307 / 313

页数：7

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