Highly efficient selection of CD4 and CD8 lineage thymocytes supports an instructive model of lineage commitment

被引：30

作者：

Itano, A ^{[1
]}

Robey, E ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

来源：

IMMUNITY | 2000年 / 12卷 / 04期

关键词：

D O I：

10.1016/S1074-7613(00)80190-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We undertook a kinetic analysis of the generation of mature T cells in TCR and coreceptor transgenic mice using BrdU labeling. We observed that the selection efficiency of mature CD4(-) CD8(+) and CD4(+)CD8(-) thymocytes could be as high as 40% and 90% of CD4(+)CD8(+) precursors, respectively. The surprisingly high efficiency of selection favors an instructional model of lineage commitment and is incompatible with a stochastic model in which the efficiency of selection would be no greater than 100% in both lineages combined.

引用

页码：383 / 389

页数：7

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