Ischemic versus idiopathic cardiomyopathy: differing neurohumoral profiles despite comparable peak oxygen uptake

被引:17
作者
Deng, MC
Brisse, B
Erren, M
Khurana, C
Breithardt, G
Scheld, HH
机构
[1] MUENSTER UNIV HOSP, DEPT THORAC & CARDIOVASC SURG, MUNSTER, GERMANY
[2] MUENSTER UNIV HOSP, DEPT CARDIOL & ANGIOL, MUNSTER, GERMANY
[3] MUENSTER UNIV HOSP, INST ARTERIOSCLEROSIS RES, MUNSTER, GERMANY
[4] MUENSTER UNIV HOSP, INST CLIN CHEM & LAB MED, MUNSTER, GERMANY
关键词
ischemic cardiomyopathy; neurohormonal regulation; T-cell immune response; spiroergometric testing;
D O I
10.1016/S0167-5273(97)00163-0
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: We tested the hypothesis that neurohormonal and immunological activation differs in ischemic and idiopathic dilated cardiomyopathy since recent intervention trials indicate that ischemic cardiomyopathy seems to carry a worse prognosis than idiopathic cardiomyopathy of comparable clinical severity. Methods: In ten patients with ischemic cardiomyopathy undergoing spiroergometric evaluation venous levels of norepinephrine, epinephrine, renin, angiotensin, atrial natriuretic peptide as well as soluble interleukin-2-receptor were determined before, during and 10 min after exercise. Results were compared to sixteen patients with idiopathic cardiomyopathy with similar peak oxygen uptake (13.3+/-3 vs. 13.6+/-3 ml/kg/min; P=ns). Results: In ischemic patients, norepinephrine, angiotensin, and interleukin-2 receptor levels were significantly higher before, during and after exercise. Interleukin-2-receptor levels correlated with angiotensin. Conclusions: We conclude that in ischemic as compared to idiopathic cardiomyopathy, a more pronounced activation of the sympathetic, renin-angiotensin and T-cell immune system is present at rest, during and after exercise. These data may contribute to explain differences in response to intervention and in prognosis. They warrant further investigation. (C) 1997 Elsevier Science Ireland Ltd.
引用
收藏
页码:261 / 268
页数:8
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