Inhibition of α-glucosidase by oleanolic acid and its synthetic derivatives

被引：129

作者：

Ali, MS ^{[1
]}

Jahangir, M ^{[1
]}

ul Hussan, SS ^{[1
]}

Choudhary, MI ^{[1
]}

机构：

[1] Univ Karachi, HEJ Res Inst Chem, Karachi 75270, Pakistan

来源：

PHYTOCHEMISTRY | 2002年 / 60卷 / 03期

关键词：

oleanolic acid; five synthetic derivatives; alpha-glucosidase inhibition; IC50; values;

D O I：

10.1016/S0031-9422(02)00104-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Oleanolic acid (1) and five synthetic derivatives (2-6) were tested spectrophotometrically for inhibition of urease, beta-lactamase, acetyl cholinesterase and a-glucosidase. All products showed a positive response only against alpha-glucosidase but not against the other enzymes; IC50 calculations showed that the dihydroxy-olide derivative (4) was the most potent among all tested samples. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：295 / 299

页数：5

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