Automated control and optimisation of ion mobility spectrometry responses using a sheath-flow inlet

被引:11
作者
Young, D
Eiceman, GA
Breach, J
Brittain, AH
Thomas, CLP
机构
[1] Univ Manchester, Inst Sci & Technol, Dept Instrumentat & Analyt Sci, Manchester M60 1QD, Lancs, England
[2] New Mexico State Univ, Dept Chem & Biochem, Las Cruces, NM 88003 USA
[3] Graseby Dynam Ltd, Watford WD2 2BW, Herts, England
基金
英国工程与自然科学研究理事会;
关键词
ion mobility spectrometry; dichloromethane; ethyl acetates; sampling; sheath-flow inlet;
D O I
10.1016/S0003-2670(02)00380-X
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
The stability and speed of the operation of sheath-flow inlet high temperature ion mobility spectrometer were studied over sampled mass fluxes in the range 0-50 ng s(-1) for dichloromethane and ethyl acetate. The response to step-changes in sheath-flow in the region of 10 cm min(-1) stabilised within 1.4 s, although, the recovery of a reponse on shutting down the sheath-flow could be longer if adsorptive memory effects had built up within the inlet at high concentrations. The effect of mass flux as opposed to sampled concentration was highlighted and the importance of the role of mixing in the reaction region in controlling ion spectrometric responses emphasised. The incorporation of a sheath-flow inlet into an automated feed-back control system was demonstrated with the system observed to maintain, without operator intervention, a linear response over an order of magnitude increase in the mass flux compared to the same instrument without the sheath-flow inlet fitted. The overall maximum sensitivity of the system was not significantly altered, and the drift time was not affected while the precision of the responses to test atmospheres was comparable to other ion mobility spectrometric systems with a RSD in the responses of less than 7%. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:143 / 154
页数:12
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