Relationship Between Cingulo-Insular Functional Connectivity and Autistic Traits in Neurotypical Adults

被引:181
作者
Di Martino, Adriana [1 ]
Shehzad, Zarrar [1 ]
Kelly, Clare [1 ]
Roy, Amy Krain [1 ]
Gee, Dylan G. [1 ]
Uddin, Lucina Q. [1 ]
Gotimer, Kristin [1 ]
Klein, Donald F. [1 ]
Castellanos, F. Xavier [1 ]
Milham, Michael P. [1 ]
机构
[1] NYU, Ctr Child Study, Phyllis Green & Randolph Cowen Inst Pediat Neuros, New York, NY 10016 USA
关键词
BRAIN; CORTEX; MIND; NETWORKS; SYSTEMS;
D O I
10.1176/appi.ajp.2009.08121894
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objective: The Social Responsiveness Scale-Adult Version (SRS-A) measures autistic traits that are continuously distributed in the general population. Based on increased recognition of the dimensional nature of autistic traits, the authors examined the neural correlates of these traits in neurotypical individuals using the SRS-A and established a novel approach to assessing the neural basis of autistic characteristics, attempting to directly relate SRS-A scores to patterns of functional connectivity observed in the pregenual anterior cingulate cortex, a region commonly implicated in social cognition. Methods: Resting state functional magnetic resonance imaging scans were collected for 25 neurotypical adults. All participants provided SRS-A ratings completed by an informant who had observed them in natural social settings. Whole brain-corrected connectivity analyses were then conducted using SRS-A scores as a covariate of interest. Results: Across participants, a significant negative relationship between SRS-A scores and the functional connectivity of the pregenual anterior cingulate cortex with the anterior portion of the mid-insula was found. Specifically, low levels of autistic traits were observed when a substantial portion of the anterior mid-insula showed positive connectivity with the pregenual anterior cingulate cortex. In contrast, elevated levels of autistic traits were associated with negative connectivity between these two regions. Conclusions: Resting state functional connectivity of the pregenual anterior cingulate cortex-insula social network was related to autistic traits in neurotypical adults. Application of this approach in samples with autism spectrum disorders is needed to confirm whether this circuit is dimensionally related to the severity of autistic traits in clinical populations.
引用
收藏
页码:891 / 899
页数:9
相关论文
共 41 条
[1]   Meeting of minds: the medial frontal cortex and social cognition [J].
Amodio, DM ;
Frith, CD .
NATURE REVIEWS NEUROSCIENCE, 2006, 7 (04) :268-277
[2]   Disruption of large-scale brain systems in advanced aging [J].
Andrews-Hanna, Jessica R. ;
Snyder, Abraham Z. ;
Vincent, Justin L. ;
Lustig, Cindy ;
Head, Denise ;
Raichle, Marcus E. ;
Buckner, Randy L. .
NEURON, 2007, 56 (05) :924-935
[3]  
Augustine J R, 1985, Neurol Res, V7, P2
[4]  
Baron-Cohen S, 2001, J CHILD PSYCHOL PSYC, V42, P241, DOI 10.1017/S0021963001006643
[5]   Statistics review 9: One-way analysis of variance [J].
Bewick, V ;
Cheek, L ;
Ball, J .
CRITICAL CARE, 2004, 8 (02) :130-136
[6]   FUNCTIONAL CONNECTIVITY IN THE MOTOR CORTEX OF RESTING HUMAN BRAIN USING ECHO-PLANAR MRI [J].
BISWAL, B ;
YETKIN, FZ ;
HAUGHTON, VM ;
HYDE, JS .
MAGNETIC RESONANCE IN MEDICINE, 1995, 34 (04) :537-541
[7]  
BRETT M, 1999, MNI BRAIN TALAIRACH, P12
[8]   Unrest at rest: Default activity and spontaneous network correlations [J].
Buckner, Randy L. ;
Vincent, Justin L. .
NEUROIMAGE, 2007, 37 (04) :1091-1096
[9]   The precuneus: a review of its functional anatomy and behavioural correlates [J].
Cavanna, AE ;
Trimble, MR .
BRAIN, 2006, 129 :564-583
[10]   Functional connectivity in a baseline resting-state network in autism [J].
Cherkassky, Vladimir L. ;
Kana, Rajesh K. ;
Keller, Timothy A. ;
Just, Marcel Adam .
NEUROREPORT, 2006, 17 (16) :1687-1690