Non-invasive diagnosis and monitoring of liver fibrosis and cirrhosis

被引：40

作者：

Denzer, Ulrike W. ^{[1
]}

Lueth, Stefan ^{[1
]}

机构：

[1] Univ Med Ctr Hamburg Eppendorf, Dept Med, D-24046 Hamburg, Germany

来源：

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY | 2009年 / 23卷 / 03期

关键词：

Liver fibrosis; cirrhosis; biochemical marker; transient elastography; fibroscan; CHRONIC HEPATITIS-C; TRANSIENT ELASTOGRAPHY; BIOCHEMICAL MARKERS; HYALURONIC-ACID; SERUM MARKERS; DISEASE; STIFFNESS; PREDICTION; COMPLICATIONS; PERFORMANCE;

D O I：

10.1016/j.bpg.2009.03.002

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The accurate staging of liver fibrosis in chronic liver diseases, especially the early diagnosis of liver cirrhosis, is crucial for prognostic assessment of the course of the disease. The histological evaluation of a liver biopsy cylinder is still the gold standard in assessing the stage of liver fibrosis. However, liver biopsy is an invasive procedure and carries the risk of complications. This has to be balanced against the information benefit of liver histology. To overcome this, non-invasive tests were developed assessing liver fibrosis based on combinations of laboratory markers or techniques measuring liver elasticity. In this review the current impact of the non invasive methods is discussed and weighted against liver biopsy. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：453 / 460

页数：8

共 47 条

[1] Acute viral hepatitis increases liver stiffness values measured by transient elastography [J].

Arena, Umberto ;

Vizzutti, Francesco ;

Corti, Giampaolo ;

Ambu, Silvia ;

Stasi, Cristina ;

Bresci, Silvia ;

Moscarella, Stefania ;

Boddi, Vied ;

Petrarca, Antonio ;

Laffi, Giacomo ;

Marra, Fabio ;

Pinzani, Massimo .

HEPATOLOGY, 2008, 47 (02) :380-384

[2] Ultrasonographic diagnosis of hepatic fibrosis or cirrhosis [J].

Aubé, C ;

Oberti, F ;

Korali, N ;

Namour, MA ;

Loisel, D ;

Tanguy, JY ;

Valsesia, E ;

Pilette, C ;

Rousselet, MC ;

Bedossa, P ;

Rifflet, H ;

Maïga, MY ;

Penneau-Fontbonne, D ;

Caron, C ;

Calès, P .

JOURNAL OF HEPATOLOGY, 1999, 30 (03) :472-478

[3]

Aubé C, 2004, J RADIOL, V85, P301

[4] Natural history of compensated viral cirrhosis:: a prospective study on the incidence and hierarchy of major complications [J].

Benvegnù, L ;

Gios, M ;

Boccato, S ;

Alberti, A .

GUT, 2004, 53 (05) :744-749

[5] Diagnostic potential of circulating TIMP-1 and MMP-2 as markers of liver fibrosis in patients with chronic hepatitis C [J].

Boeker, KHW ;

Haberkorn, CI ;

Michels, D ;

Flemming, P ;

Manns, MP ;

Lichtinghagen, R .

CLINICA CHIMICA ACTA, 2002, 316 (1-2) :71-81

[6] Diffusion-weighted MR imaging of the liver of hepatitis C patients [J].

Boulanger, Y ;

Amara, M ;

Lepanto, L ;

Beaudoin, G ;

Nguyen, BN ;

Allaire, G ;

Poliquin, M ;

Nicolet, V .

NMR IN BIOMEDICINE, 2003, 16 (03) :132-136

[7] Prospective randomized comparison of minilaparoscopy and percutaneous liver biopsy -: Diagnosis of cirrhosis and complications [J].

Denzer, Ulrike ;

Arnoldy, Andrea ;

Kanzler, Stefan ;

Galle, Peter R. ;

Dienes, Hans P. ;

Lohse, Ansgar W. .

JOURNAL OF CLINICAL GASTROENTEROLOGY, 2007, 41 (01) :103-110

[8] Serum laminin, type IV collagen and hyaluronan as fibrosis markers in non-alcoholic fatty liver disease [J].

dos Santos, VN ;

Leite-Mór, MMB ;

Kondo, M ;

Martins, JR ;

Nader, H ;

Lanzoni, VP ;

Parise, ER .

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 2005, 38 (05) :747-753

[9] Efficacy of interferon treatment for patients with chronic hepatitis C: Comparison of response in cirrhotics, fibrotics, or nonfibrotics [J].

Everson, GT ;

Jensen, DM ;

Craig, JR ;

van Leeuwen, DJ ;

Bain, VG ;

Ehrinpreis, MN ;

Albert, D ;

Joh, T ;

Witt, K .

HEPATOLOGY, 1999, 30 (01) :271-276

[10] Identification of chronic hepatitis C patients without hepatic fibrosis by a simple predictive model [J].

Forns, X ;

Ampurdanès, S ;

Llovet, JM ;

Aponte, J ;

Quintó, L ;

Martínez-Bauer, E ;

Bruguera, M ;

Sánchez-Tapias, JM ;

Rodés, J .

HEPATOLOGY, 2002, 36 (04) :986-992

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