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Progress and obstacles in the development of an AIDS vaccine

被引：125
作者：
Letvin, Norman L. [1 ]
机构：
[1] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Med,Div Viral Pathogenesis, Boston, MA 02215 USA
来源：
NATURE REVIEWS IMMUNOLOGY | 2006年 / 6卷 / 12期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nri1959
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Recent experimental observations suggest approaches to immunization that might finally result in at least a partially effective vaccine against infection with HIV-1. In particular, advances in our understanding of the contribution of vaccine-elicited cellular immunity to protecting memory CD4(+) T cells from virus-mediated destruction provide rational strategies for the development of this vaccine. This is therefore an ideal time to review our current understanding of HIV-1 and its control by the immune system, as well as the remaining problems that must be solved to facilitate the development of an effective vaccine against AIDS.
引用
收藏
页码：930 / 939
页数：10
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