Calcineurin contributes to spatial memory impairment induced by rapid eye movement sleep deprivation

被引：38

作者：

Wang, Gui-Ping

Huang, Liu-Qing

Wu, Hui-Juan

Zhang, Lin

You, Zhen-Dong

Zhao, Zhong-Xin ^{[1
]}

机构：

[1] Second Mil Med Univ, Changzheng Hosp, Dept Neurol, Neurosci Res Ctr,Inst Neurosci, Shanghai 200003, Peoples R China

来源：

NEUROREPORT | 2009年 / 20卷 / 13期

关键词：

calcineurin; rapid eye movement sleep; sleep deprivation; spatial memory; NMDA RECEPTOR TRAFFICKING; LONG-TERM POTENTIATION; WATER MAZE; REM-SLEEP; PLASTICITY; INHIBITION; INDUCTION; CHANNELS; DEFICITS; STRESS;

D O I：

10.1097/WNR.0b013e32832f0772

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent evidence suggests that rapid eye movement (REM) sleep deprivation (REMSD) causes learning and memory deficits. However, the mechanism of REMSD-induced memory impairment remains unclear. Calcineurin (CaN) is involved in synaptic plasticity and is known as a negative constraint on learning and memory. Here we report that 72 h REMSD by the modified multiple platform method in rats resulted in spatial memory impairment in the Morris water maze and elevated hippocampal cytosolic CaN activity, both of which were reversed after 18h sleep recovery. CaN expression in the whole-tissue homogenate of the hippocampus was not altered by REMSD. The results suggest that elevated hippocampal CaN activity is involved in REMSD-induced spatial memory impairment. NeuroReport 20:1172-1176 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

引用

页码：1172 / 1176

页数：5

共 25 条

[1] Voltage-gated channels block nicotinic regulation of CREB phosphorylation and gene expression in neurons [J].

Chang, KT ;

Berg, DK .

NEURON, 2001, 32 (05) :855-865

[2] Altered NMDA receptor trafficking contributes to sleep deprivation-induced hippocampal synaptic and cognitive impairments [J].

Chen, C ;

Hardy, M ;

Zhang, J ;

LaHoste, GJ ;

Bazan, NG .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 340 (02) :435-440

[3] REM sleep deprivation-induced deficits in the latency-to-peak induction and maintenance of long-term potentiation within the CA1 region of the hippocampus [J].

Davis, CJ ;

Harding, JW ;

Wright, JW .

BRAIN RESEARCH, 2003, 973 (02) :293-297

[4] Calcineurin links Ca2+ dysregulation with brain aging [J].

Foster, TC ;

Sharrow, KM ;

Masse, JR ;

Norris, CM ;

Kumar, A .

JOURNAL OF NEUROSCIENCE, 2001, 21 (11) :4066-4073

[5] Protein phosphatase 1 is a molecular constraint on learning and memory [J].

Genoux, D ;

Haditsch, U ;

Knobloch, M ;

Michalon, A ;

Storm, D ;

Mansuy, IM .

NATURE, 2002, 418 (6901) :970-975

[6] Sleep and memory: a molecular perspective [J].

Graves, L ;

Pack, A ;

Abel, T .

TRENDS IN NEUROSCIENCES, 2001, 24 (04) :237-243

[7] Calcineurin regulation of neuronal plasticity [J].

Groth, RD ;

Dunbar, RL ;

Mermelstein, PG .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 311 (04) :1159-1171

[8] Selective changes of calcineurin (protein phosphatase 2B) activity in Alzheimer's disease cerebral cortex [J].

Lian, QY ;

Ladner, CJ ;

Magnuson, D ;

Lee, JM .

EXPERIMENTAL NEUROLOGY, 2001, 167 (01) :158-165

[9] Sleep deprivation induced by the modified multiple platform technique:: quantification of sleep loss and recovery [J].

Machado, RB ;

Hipólide, DC ;

Benedito-Silva, AA ;

Tufik, S .

BRAIN RESEARCH, 2004, 1004 (1-2) :45-51

[10] Inducible and reversible enhancement of learning, memory, and long-term potentiation by genetic inhibition of calcineurin [J].

Malleret, G ;

Haditsch, U ;

Genoux, D ;

Jones, MW ;

Bliss, TVP ;

Vanhoose, AM ;

Weitlauf, C ;

Kandel, ER ;

Winder, DG ;

Mansuy, IM .

CELL, 2001, 104 (05) :675-686

← 1 2 3 →