One-pot synthesis of tetrasubstited pyrazoles - Proof of regiochemistry

被引：69

作者：

Hanefeld, U

Rees, CW

White, AJP

Williams, DJ

机构：

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1996年 / 13期

关键词：

D O I：

10.1039/p19960001545

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1-Alkyl-5-amino-3-aryl-4-cyanopyrazoles, useful intermediates for fused heterocyclic systems, are synthesised by a one-pot three-step procedure from acid chlorides, malononitrile and alkylhydrazines, The regiochemistry of the hydrazine incorporation was proved in each case by X-ray crystallography and NMR spectroscopy.

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页码：1545 / 1552

页数：8

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