Experimental studies with foot-and-mouth disease virus, strain O, responsible for the 2001 epidemic in the United Kingdom

被引：35

作者：

Aggarwal, N ^{[1
]}

Zhang, Z ^{[1
]}

Cox, S ^{[1
]}

Statham, R ^{[1
]}

Alexandersen, S ^{[1
]}

Kitching, RP ^{[1
]}

Barnett, PV ^{[1
]}

机构：

[1] AFRC, Inst Anim Hlth, Pirbright Lab, Woking GU24 0NF, Surrey, England

来源：

VACCINE | 2002年 / 20卷 / 19-20期

关键词：

foot-and-mouth disease; vaccination; persistence;

D O I：

10.1016/S0264-410X(02)00178-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In 200 1, the United Kingdom experienced its worst epidemic of foot-and-mouth disease (FMD). To date approximately 3.9 million animals have been culled and direct and indirect revenue losses are probably in excess of pound12 billion. This study was carried out to investigate the biological characteristics of the FMD virus strain O/UKG/2001 responsible for the epidemic. Animal transmission experiments indicated that this strain is not host restricted and will infect the three main susceptible livestock species (cattle, sheep and pigs). Immunisation with high potency emergency vaccine derived from O-1 Manisa strain of FMD virus protected all three species against clinical disease when challenged with FMD virus strain O/UKG/2001. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2508 / 2515

页数：8

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