Calcitriol and lexicalcitol (KH1060) inhibit the growth of human breast adenocarcinoma cells by enhancing transforming growth factor-beta production

被引:20
作者
Mercier, T [1 ]
Chaumontet, C [1 ]
GaillardSanchez, I [1 ]
Martel, P [1 ]
Heberden, C [1 ]
机构
[1] INRA,CRJ,LAB NUTR & SCEURITE ALIMENTAIRE,F-78352 JOUY EN JOSAS,FRANCE
关键词
calcitriol; 1,25-dihydroxyvitamin-D-3; KH1060; TGF-beta; MCF-7; cells;
D O I
10.1016/0006-2952(96)00254-7
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The mechanisms involved in the antiproliferative action of calcitriol (1 alpha,25(OH)(2)D-3) were investigated using human breast carcinoma epithelial cells (the MCF-7 cell line). Calcitriol and KH1060, a synthetic analog, inhibited cell growth in a time- and dose-dependent way. The substances similarly stimulated total TGF-beta secretion after 24 hours, and Northern blot analyses showed that mRNA levels for TGF-beta 1 were increased, as well. When MCF-7 cells were co-incubated with calcitriol and a neutralizing antiTGF-beta 1,beta 2,beta 3 antibody, growth inhibition was completely abrogated. With KH1060, the antibody could only partly block growth inhibition. This study shows that TCF-beta is involved in the growth response to calcitriol and KH1060 in MCF-7 cells.
引用
收藏
页码:505 / 510
页数:6
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