Towards nucleopeptides containing any trifunctional amino acid (II)

被引：18

作者：

Debéthune, L ^{[1
]}

Marchán, V ^{[1
]}

Fàbregas, G ^{[1
]}

Pedroso, E ^{[1
]}

Grandas, A ^{[1
]}

机构：

[1] Univ Barcelona, Fac Quim, Dept Quim Organ, E-08028 Barcelona, Spain

来源：

TETRAHEDRON | 2002年 / 58卷 / 34期

关键词：

nucleopeptide; arginine; asparagine; cysteine; protection;

D O I：

10.1016/S0040-4020(02)00793-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Nucleopeptides with no restriction in the amino acid composition can be synthesized using stepwise solid-phase methodology. Best conditions for the protection of arginine and cysteine, as well as for the final deprotection treatment are established, and our conclusions can be extended to the preparation of any peptide-oligonucleotide hybrid. The association between certain side reactions and nucleopeptide sequences is also discussed. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：6965 / 6978

页数：14

共 64 条

[1]

Antopolsky M, 1999, HELV CHIM ACTA, V82, P2130, DOI 10.1002/(SICI)1522-2675(19991215)82:12<2130::AID-HLCA2130>3.0.CO

[2]

2-A

[3] Stepwise solid-phase synthesis of peptide-oligonucleotide phosphorothioate conjugates employing Fmoc peptide chemistry [J].

Antopolsky, M ;

Azhayev, A .

TETRAHEDRON LETTERS, 2000, 41 (47) :9113-9117

[4]

BARANY G, 1980, SPECIAL METHODS PE A, V2, P193

[5]

BARANY G, 1980, SPECIAL METHODS PE A, V2, P204

[6]

BARANY G, 1980, SPECIAL METHODS PEPT, V2, P174

[7]

BARANY G, 1980, SPECIAL METHODS PE A, V2, P206

[8] A comparison of histidine protecting groups in the synthesis of peptide-oligonucleotide conjugates [J].

Beltrán, M ;

Pedroso, E ;

Grandas, A .

TETRAHEDRON LETTERS, 1998, 39 (23) :4115-4118

[9] Study of the interaction between a histidine-deoxyguanosine hybrid and cisplatin [J].

Beltrán, M ;

Onoa, GB ;

Pedroso, E ;

Moreno, V ;

Grandas, A .

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 1999, 4 (06) :701-707

[10]

Beltran M, 1997, LETT PEPT SCI, V4, P147

← 1 2 3 4 5 6 7 →