Acute eosinophilic pneumonia associated with intramuscular administration of progesterone as luteal phase support after IVF: Case report

被引:35
作者
Bouckaert, Y
Robert, F
Englert, Y
De Backer, D
De Vuyst, P
Delbaere, A
机构
[1] Free Univ Brussels, Erasme Hosp, Fertil Clin, B-1070 Brussels, Belgium
[2] Free Univ Brussels, Erasme Hosp, Dept Intens Care, B-1070 Brussels, Belgium
[3] Free Univ Brussels, Erasme Hosp, Dept Chest, B-1070 Brussels, Belgium
关键词
benzyl alcohol; eosinophilic pneumonia; IVF; progesterone; sesame oil;
D O I
10.1093/humrep/deh316
中图分类号
R71 [妇产科学];
学科分类号
100211 [妇产科学];
摘要
We report two cases of acute eosinophilic pneumonia induced by i.m. administration of progesterone used as luteal phase support after IVF. For both patients, the symptoms began 3 weeks after the first injection of progesterone. Both patients were in respiratory distress, and one of them required ventilatory assistance for a week, with 5 days in the intensive care unit. Symptoms improved as the i.m. form was shifted to a vaginal form of progesterone together with the administration of corticosteroids. Sesame oil (used as excipient) and benzyl alcohol (used as preservative) could both be incriminated in the development of the hypersensitivity reaction. The need for luteal phase support is clearly established in IVF cycles with GnRH agonist protocols, and progesterone is the generally recommended compound. However, there is no definitive consensus regarding the optimal route of administration of progesterone. These two cases of acute drug-induced disease show that the use of i.m. progesterone can be associated with a severe morbidity in otherwise healthy young patients. This is an additional argument to advocate the use of vaginal progesterone as luteal support in IVF.
引用
收藏
页码:1806 / 1810
页数:5
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