Random versus directionally persistent cell migration

被引：733

作者：

Petrie, Ryan J. ^{[1
]}

Doyle, Andrew D. ^{[1
]}

Yamada, Kenneth M. ^{[1
]}

机构：

[1] Natl Inst Dent & Craniofacial Res, Lab Cell & Dev Biol, NIH, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2009年 / 10卷 / 08期

关键词：

SIGNAL-TRANSDUCTION PATHWAYS; ACTIN-DEPOLYMERIZING FACTOR; TYROSINE KINASE ROR2; CONTACT GUIDANCE; LEADING-EDGE; FOCAL ADHESIONS; STRESS FIBERS; GROWTH-FACTOR; RHO-GTPASES; RAC ACTIVATION;

D O I：

10.1038/nrm2729

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Directional migration is an important component of cell motility. Although the basic mechanisms of random cell movement are well characterized, no single model explains the complex regulation of directional migration. Multiple factors operate at each step of cell migration to stabilize lamellipodia and maintain directional migration. Factors such as the topography of the extracellular matrix, the cellular polarity machinery, receptor signalling, integrin trafficking, integrin co-receptors and actomyosin contraction converge on regulation of the Rho family of GTPases and the control of lamellipodial protrusions to promote directional migration.

引用

页码：538 / 549

页数：12

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