Synthesis of allylic trifluoromethyl alcohols from 1-trifluoromethyl-epoxy ethers

被引：5

作者：

Begue, JP ^{[1
]}

BonnetDelpon, D ^{[1
]}

Kornilov, A ^{[1
]}

FischerDurand, N ^{[1
]}

机构：

[1] UKRAINIAN ACAD SCI,INST BIOORGAN CHEM & PETROCHEM,UA-253160 KIEV,UKRAINE

来源：

JOURNAL OF FLUORINE CHEMISTRY | 1996年 / 80卷 / 01期

关键词：

synthesis; allylic trifluoromethyl alcohols; epoxy ethers; alpha-thiophenyl ketones; NMR spectroscopy;

D O I：

10.1016/S0022-1139(96)03452-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

alpha-Thiophenyl ketones are easily available by the regioselective ring-opening of 1-trifluoromethyl-epoxy ethers with phenyl sodium thiolate. Their in situ reduction with NaBH4, followed by oxidation with NaIO4 and thermal decomposition of the resultant sulphoxides, provided allylic trifluoromethyl alcohols in high overall yield.

引用

页码：13 / 16

页数：4

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