Viral OTU Deubiquitinases: A Structural and Functional Comparison

被引：34

作者：

Bailey-Elkin, Ben A. ^{[1
]}

van Kasteren, Puck B. ^{[2
]}

Snijder, Eric J. ^{[2
]}

Kikkert, Marjolein ^{[2
]}

Mark, Brian L. ^{[1
]}

机构：

[1] Univ Manitoba, Dept Microbiol, Winnipeg, MB R3T 2N2, Canada

[2] Leiden Univ, Med Ctr, Dept Med Microbiol, Mol Virol Lab, Leiden, Netherlands

来源：

PLOS PATHOGENS | 2014年 / 10卷 / 03期

基金：

加拿大自然科学与工程研究理事会;

关键词：

PAPAIN-LIKE PROTEASE; RESPIRATORY SYNDROME CORONAVIRUS; DEPENDENT RNA-POLYMERASE; NONSTRUCTURAL PROTEIN-2; CYSTEINE PROTEASES; VIRUS; UBIQUITIN; DOMAIN; ARTERIVIRUS; ISG15;

D O I：

10.1371/journal.ppat.1003894

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Recent studies have revealed that proteases encoded by three very diverse RNA virus groups share structural similarity with enzymes of the Ovarian Tumor (OTU) superfamily of deubiquitinases (DUBs). The publication of the latest of these reports in quick succession prevented proper recognition and discussion of the shared features of these viral enzymes. Here we provide a brief structural and functional comparison of these virus-encoded OTU DUBs. Interestingly, although their shared structural features and substrate specificity tentatively place them within the same protease superfamily, they also show interesting differences that trigger speculation as to their origins.

引用

页数：6

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