Mitochondrial uncoupling: A key contributor to reduced cardiac efficiency in diabetes

被引：136

作者：

Boudina, Sihem ^{[1
]}

Abel, E. Dale

机构：

[1] Univ Utah, Sch Med, Div Endocrinol Diabet & Metab, Salt Lake City, UT 84112 USA

[2] Univ Utah, Sch Med, Program Human Mol Biol & Genet, Salt Lake City, UT USA

来源：

PHYSIOLOGY | 2006年 / 21卷

关键词：

D O I：

10.1152/physiol.00008.2006

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Cardiovascular disease is the primary cause of death in individuals with obesity and diabetes. However, the underlying mechanisms for cardiac dysfunction are partially understood. Studies have suggested that altered cardiac metabolism may play a role. The diabetic heart is characterized by increased fatty acid oxidation, increased myocardial oxygen consumption, and reduced cardiac efficiency. Here, we review possible mechanisms for reduced cardiac efficiency in obesity and diabetes by focusing on the potential role of mitochondrial uncoupling.

引用

页码：250 / 258

页数：9

共 111 条

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