Drug-induced QT interval prolongation after ciprofloxacin administration in a patient receiving olanzapine

被引：31

作者：

Letsas, Konstantinos P.

Sideris, Antonios

Kounas, Stavros P.

Efremidis, Michalis

Korantzopoulos, Panagiotis ^{[1
]}

Kardaras, Fotios

机构：

[1] G Hatzikosta Gen Hosp, Dept Cardiol, Ioannina 45001, Greece

[2] Evangelismos Gen Hosp Athens, Dept Cardiol 2, Athens 10676, Greece

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2006年 / 109卷 / 02期

关键词：

ciprofloxacin; olanzapine; adverse reactions; acquired long QT; QT prolongation;

D O I：

10.1016/j.ijcard.2005.04.031

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Several non-antiarrhythmic drugs including antibiotic and antipsychotic agents have been shown to prolong cardiac repolarization predisposing to torsade de pointes ventricular tachycardia. Blockade of the delayed rectifier (repolarising) potassium current and drug interactions with inhibitors of the CYP-mediated metabolism are the most common underlying mechanisms. In the present case report, art elderly woman receiving a long-term medication with azathioprine, olanzapine and valsartan developed a marked QT interval prolongation after intravenous administration of ciprofloxacin. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：273 / 274

页数：2

共 10 条

[1] Olanzapine - Pharmacokinetic and pharmacodynamic profile [J].