MicroRNAs in cancer: biomarkers, functions and therapy

被引：2260

作者：

Hayes, Josie ^{[1
,2
]}

Peruzzi, Pier Paolo ^{[3
]}

Lawler, Sean ^{[4
]}

机构：

[1] St James Univ Hosp, Leeds Inst Canc & Pathol, Leeds LS9 7TF, W Yorkshire, England

[2] St James Univ Hosp, Yorkshire Reg Cytogenet Unit, Leeds LS9 7TF, W Yorkshire, England

[3] Ohio State Univ, Med Ctr, Dept Neurosurg, Columbus, OH 43210 USA

[4] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Neurosurg, Boston, MA 02115 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2014年 / 20卷 / 08期

关键词：

microRNA; cancer; clinical; prognosis; signature; EPITHELIAL-MESENCHYMAL TRANSITION; CIRCULATING MICRORNAS; PRECURSOR MICRORNAS; EXPRESSION PROFILES; DOWN-REGULATION; LET-7; MICRORNA; SMALL RNAS; CELL; GENE; CHEMORESISTANCE;

D O I：

10.1016/j.molmed.2014.06.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The emergence of microRNAs has been one of the defining developments in cancer biology over the past decade, and the explosion of knowledge in this area has brought forward new diagnostic and therapeutic opportunities. The importance of microRNAs in cancer has been underlined by the identification of alterations in microRNA target binding sites and the microRNA processing machinery in tumor cells. Clinical trials utilizing microRNA profiling for patient prognosis and clinical response are now underway, and the first microRNA mimic entered the clinic for cancer therapy in 2013. In this article we review the potential applications of microRNAs for the clinical assessment of patient outcome in cancer, as well as in cancer monitoring and therapy.

引用

页码：460 / 469

页数：10

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