Low-Grade Gliomas

被引：183

作者：

Forst, Deborah A. ^{[1
]}

Nahed, Brian V. ^{[2
]}

Loeffler, Jay S. ^{[3
]}

Batchelor, Tracy T. ^{[1
,3
,4
]}

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Neurol, Boston, MA USA

[2] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Neurosurg, Boston, MA USA

[3] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Radiat Oncol, Boston, MA USA

[4] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Div Hematol & Oncol, Boston, MA USA

来源：

ONCOLOGIST | 2014年 / 19卷 / 04期

关键词：

Glioma; Astrocytoma; Oligodendroglioma; Surgery; Radiation; QUALITY-OF-LIFE; RADIATION-THERAPY; RANDOMIZED-TRIAL; PILOCYTIC ASTROCYTOMA; SURGICAL RESECTION; RESPONSE CRITERIA; IDH2; MUTATIONS; DOSE-RESPONSE; PHASE-II; SURVIVAL;

D O I：

10.1634/theoncologist.2013-0345

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Low-grade gliomas (LGGs) are a diverse group of primary brain tumors that often arise in young, otherwise healthy patients and generally have an indolent course with longer-term survival in comparison with high-grade gliomas. Treatment options include observation, surgery, radiation, chemotherapy, or a combined approach, and management is individualized based on tumor location, histology, molecular profile, and patient characteristics. Moreover, in this type of brain tumor with a relatively good prognosis and prolonged survival, the potential benefits of treatment must be carefully weighed against potential treatment-related risks. We review in this article current management strategies for LGG, including surgery, radiotherapy, and chemotherapy. In addition, the importance of profiling the genetic and molecular properties of LGGs in the development of targeted anticancer therapies is also reviewed. Finally, given the prevalence of these tumors in otherwise healthy young patients, the impact of treatment on neurocognitive function and quality of life is also evaluated.

引用

页码：403 / 413

页数：11

共 55 条

[1]

Afra D, 1999, BRIT J NEUROSURG, V13, P299

[2] Detection of 2-Hydroxyglutarate in IDH-Mutated Glioma Patients by In Vivo Spectral-Editing and 2D Correlation Magnetic Resonance Spectroscopy [J].

Andronesi, Ovidiu C. ;

Kim, Grace S. ;

Gerstner, Elizabeth ;

Batchelor, Tracy ;

Tzika, Aria A. ;

Fantin, Valeria R. ;

Vander Heiden, Matthew G. ;

Sorensen, A. Gregory .

SCIENCE TRANSLATIONAL MEDICINE, 2012, 4 (116)

[3]

[Anonymous], 2007, WHO CLASSIFICATION T

[4] Management of pilocytic astrocytoma with diffuse leptomeningeal spread: two cases and review of the literature [J].

Aryan, HE ;

Meltzer, HS ;

Lu, DC ;

Ozgur, BM ;

Levy, ML ;

Bruce, DA .

CHILDS NERVOUS SYSTEM, 2005, 21 (06) :477-481

[5] Diffusion MRI in the early diagnosis of malignant glioma [J].

Baehring, Joachim M. ;

Bi, Wenya Linda ;

Bannykh, Serguei ;

Piepmeier, Joseph M. ;

Fulbright, Robert K. .

JOURNAL OF NEURO-ONCOLOGY, 2007, 82 (02) :221-225

[6] Low-grade glioma: a challenge in therapeutic options: the role of radiotherapy [J].

Baumert, B. G. ;

Stupp, R. .

ANNALS OF ONCOLOGY, 2008, 19 :217-222

[7]

Baumert BG, 2013, PROC AM SOC CLIN ONC

[8] Mutations in CIC and FUBP1 Contribute to Human Oligodendroglioma [J].

Bettegowda, Chetan ;

Agrawal, Nishant ;

Jiao, Yuchen ;

Sausen, Mark ;

Wood, Laura D. ;

Hruban, Ralph H. ;

Rodriguez, Fausto J. ;

Cahill, Daniel P. ;

McLendon, Roger ;

Riggins, Gregory ;

Velculescu, Victor E. ;

Oba-Shinjo, Sueli Mieko ;

Marie, Suely Kazue Nagahashi ;

Vogelstein, Bert ;

Bigner, Darell ;

Yan, Hai ;

Papadopoulos, Nickolas ;

Kinzler, Kenneth W. .

SCIENCE, 2011, 333 (6048) :1453-1455

[9]

Central Brain Tumor Registry of the United States, 2012, STATISTICAL REPORT P

[10] Seizure characteristics and control following resection in 332 patients with low-grade gliomas [J].

Chang, Edward F. ;

Potts, Matthew B. ;

Keles, G. Evren ;

Lamborn, Kathleen R. ;

Chang, Susan M. ;

Barbaro, Nicholas M. ;

Berger, Mitchel S. .

JOURNAL OF NEUROSURGERY, 2008, 108 (02) :227-235

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