Alzheimer disease: presenilin springs a leak

被引：13

作者：

Gandy, Sam ^{[1
]}

Doeven, Mark K.

Poolman, Bert

机构：

[1] Thomas Jefferson Univ, Farber Inst Neurosci, Philadelphia, PA 19107 USA

[2] Univ Groningen, Dept Biochem, Groningen Biomol Sci & Biotechnol Inst, NL-9747 AG Groningen, Netherlands

来源：

NATURE MEDICINE | 2006年 / 12卷 / 10期

关键词：

D O I：

10.1038/nm1006-1121

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Presenilins are thought to contribute to Alzheimer disease through a protein cleavage reaction that produces neurotoxic amyloid-beta peptides. A new function for presenilins now comes to light - controlling the leakage of calcium out of the endoplasmic reticulum. Is this a serious challenge to the 'amyloid hypothesis' of Alzheimer disease?

引用

页码：1121 / 1123

页数：4

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