Epidemiology of Whipple's disease in Germany - Analysis of 110 patients diagnosed in 1965-95

被引:42
作者
vonHerbay, A
Otto, HF
Stolte, M
Borchard, F
Kirchner, T
Ditton, HJ
Maiwald, M
机构
[1] UNIV HEIDELBERG,INST MED MICROBIOL & HYG,D-69120 HEIDELBERG,GERMANY
[2] COMMUNITY HOSP,INST PATHOL,BAYREUTH,GERMANY
[3] UNIV DUSSELDORF,INST PATHOL,D-4000 DUSSELDORF,GERMANY
[4] UNIV ERLANGEN NURNBERG,INST PATHOL,D-8520 ERLANGEN,GERMANY
关键词
epidemiology; Tropheryma whippelii infection; Whipple's disease;
D O I
10.3109/00365529709025063
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background: The epidemiology of Whipple's disease (WD) is obscure. To obtain basic data, we performed an evaluation of WD patients in Germany. Methods: Information was collected from 110 WD patients diagnosed during 1965-95 at 5 institutions in different regions of Germany. Four items were evaluated: 1) year in which the diagnosis was made; 2) residence and 3) age at the time of diagnosis; and 4) sex. Results: WD patients originated from all parts of Germany. The incidence of new cases was relatively stable, with a mean of one to two cases per year per collecting centre. In 1995, a maximum of 13 new WD patients was diagnosed. There was a significant increase in the mean age of patients (1965-75, 48.7 years; confidence interval, +/-3.98 years; 1976-85, 50.7 years, +/-3.69 years; 1986-95, 57.0: years, +/-2.80 years; P < 0.01) and an increasing proportion of women (1965-85, 4%; 1986-1995, 22%). Conclusions: Whipple's disease is not quite as rare as commonly assumed. There is no obvious geographic predominance. During the past three decades, the demography of WD patients has changed.
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页码:52 / 57
页数:6
相关论文
共 23 条
[1]   CLINICOIMMUNOLOGICAL AND ELECTRON-MICROSCOPIC FINDINGS IN WHIPPLES DISEASES [J].
BUCHHOLZ, K ;
MAINTZ, J ;
OTTO, HF .
KLINISCHE WOCHENSCHRIFT, 1974, 52 (14) :672-677
[2]  
DOBBINS WO, 1987, WHIPPLES DIS
[3]   WHIPPLES-DISEASE - A HISTOLOGICAL, IMMUNOCYTOCHEMICAL, AND ELECTRON-MICROSCOPIC STUDY OF THE SMALL-INTESTINAL EPITHELIUM [J].
ECTORS, NL ;
GEBOES, KJ ;
DEVOS, RM ;
HEIDBUCHEL, HP ;
RUTGEERTS, PJ ;
DESMET, VJ .
JOURNAL OF PATHOLOGY, 1994, 172 (01) :73-79
[4]   WHIPPLES DISEASE - A REVIEW OF LITERATURE AND REPORT OF 15 PATIENTS [J].
ENZINGER, FM ;
HELWIG, EB .
VIRCHOWS ARCHIV FUR PATHOLOGISCHE ANATOMIE UND PHYSIOLOGIE UND FUR KLINISCHE MEDIZIN, 1963, 336 (03) :238-+
[5]   WHIPPLES DISEASE - CLINICAL, BIOCHEMICAL, AND HISTOPATHOLOGIC FEATURES AND ASSESSMENT OF TREATMENT IN 29 PATIENTS [J].
FLEMING, JL ;
WIESNER, RH ;
SHORTER, RG .
MAYO CLINIC PROCEEDINGS, 1988, 63 (06) :539-551
[6]   ENDOSCOPIC FINDINGS IN WHIPPLES DISEASE [J].
GAERTNER, U ;
PETZOLD, D ;
HEISIG, N ;
VOGEL, P ;
OTTO, HF .
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, 1978, 103 (44) :1740-&
[7]  
Klugmann H J, 1987, Dtsch Z Verdau Stoffwechselkr, V47, P280
[8]  
LEIDIG P, 1994, Z GASTROENTEROL, V32, P109
[9]   WHIPPLES DISEASE - A REVIEW OF 19 PATIENTS FROM ONE HOSPITAL AND A REVIEW OF LITERATURE SINCE 1950 [J].
MAIZEL, H ;
RUFFIN, JM ;
DOBBINS, WO .
MEDICINE, 1970, 49 (03) :175-+
[10]   WHIPPLES DISEASE-ASSOCIATED WITH OPPORTUNISTIC INFECTIONS [J].
MEIERWILLERSEN, HJ ;
MAIWALD, M ;
VONHERBAY, A .
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, 1993, 118 (23) :854-860