Fatty kidney: emerging role of ectopic lipid in obesity-related renal disease

被引：478

作者：

de Vries, Aiko P. J. ^{[1
]}

Ruggenenti, Piero ^{[5
,6
]}

Ruan, Xiong Z. ^{[7
,8
]}

Praga, Manuel ^{[9
,10
]}

Cruzado, Josep M. ^{[11
]}

Bajema, Ingeborg M. ^{[2
]}

D'Agati, Vivette D. ^{[12
]}

Lamb, Hildo J. ^{[3
,4
]}

Barlovic, Drazenka Pongrac ^{[13
]}

Hojs, Radovan ^{[14
,15
]}

Abbate, Manuela ^{[5
]}

Rodriquez, Rosa ^{[16
]}

Mogensen, Carl Erik ^{[17
]}

Porrini, Esteban ^{[18
]}

机构：

[1] Leiden Univ, Dept Nephrol, Med Ctr, POB 9600, NL-2300 RC Leiden, Netherlands

[2] Leiden Univ, Dept Pathol, Med Ctr, Leiden, Netherlands

[3] Leiden Univ, Dept Radiol, Med Ctr, Leiden, Netherlands

[4] Leiden Univ, Leiden, Netherlands

[5] IRCCS Ist Ric Farmacol Mario Negri, Clin Res Ctr Rare Dis Aldo Cele Dacc, Bergamo, Italy

[6] Unit Nephrol & Dialysis, Bergamo, Italy

[7] UCL, Moorhead Renal Res Lab, London, England

[8] Shenzhen Univ, Ctr Nephrol & Urol, Hlth Sci Ctr, Shenzhen, Peoples R China

[9] Univ Complutense, Hosp Octubre 12, Dept Nephrol, Madrid, Spain

[10] Univ Complutense, Hosp Octubre 12, Dept Med, Madrid, Spain

[11] Hosp Univ Bellvitge, Dept Nephrol, Barcelona, Spain

[12] Columbia Univ, Dept Pathol, Med Ctr, New York, NY USA

[13] Univ Ljubljana, Dept Endocrinol Diabet & Metab, Med Ctr, Ljubljana, Slovenia

[14] Univ Maribor, Univ Clin Ctr, Dept Nephrol, Clin Internal Med, Maribor, Slovenia

[15] Univ Maribor, Fac Med, Maribor, Slovenia

[16] Hosp Univ Canarias, Dept Pathol, Tenerife, Spain

[17] Aarhus Univ Hosp, Dept Med, Aarhus, Denmark

[18] Univ La Laguna, Ctr Biomed Res Canary Isl CIBICAN, Tenerife, Spain

来源：

LANCET DIABETES & ENDOCRINOLOGY | 2014年 / 2卷 / 05期

基金：

中国国家自然科学基金;

关键词：

BODY-MASS INDEX; FOCAL SEGMENTAL GLOMERULOSCLEROSIS; GLOMERULAR-FILTRATION-RATE; LOW-DENSITY LIPOPROTEIN; HUMAN MESANGIAL CELLS; METABOLIC SYNDROME; DIABETIC-NEPHROPATHY; INSULIN-RESISTANCE; MAMMALIAN TARGET; RISK-FACTORS;

D O I：

10.1016/S2213-8587(14)70065-8

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The global increase in chronic kidney disease (CKD) parallels the obesity epidemic. Obesity conveys a gradual but independent risk of progression of CKD that seems irrespective of the underlying nephropathy. Obesity has been associated with a secondary focal segmental glomerulosclerosis coined obesity-related glomerulopathy (ORG). Pathways through which obesity might cause renal disease are not well understood, and early clinical biomarkers for incipient ORG or renal relevant obesity are currently lacking. Recent human and experimental studies have associated ectopic lipid accumulation in the kidney (fatty kidney) with obesity-related renal disease. There is enough growing insight that ectopic lipid-the accumulation of lipid in non-adipose tissue-is associated with structural and functional changes of mesangial cells, podocytes, and proximal tubular cells to propose the development of ORG as a maladaptive response to hyperfiltration and albuminuria. Recent advances in metabolic imaging might validate ectopic lipid as a biomarker and research aid, to help translate novel therapeutics from experimental models to patients.

引用

页码：417 / 426

页数：10

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