The road to maleness: from testis to Wolffian duct

被引：27

作者：

Barsoum, Ivraym

Yao, Humphrey Hung-Chang ^{[1
]}

机构：

[1] Univ Illinois, Dept Cell & Dev Biol, Urbana, IL 61801 USA

[2] Univ Illinois, Dept Vet Biosci, Urbana, IL 61801 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2006年 / 17卷 / 06期

关键词：

D O I：

10.1016/j.tem.2006.06.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The establishment of the male internal reproductive system involves two crucial events: the formation of the testis and the maintenance and differentiation of the Wollffian duct. Testis formation, particularly the specification of Sertoli cell and Leydig cell lineages, is controlled strictly by genetic components initiated by the testis-determining gene SRY (sex-determining region of the Y chromosome). Conversely, Wolffian duct differentiation is not directly mediated via the composition of the sex chromosome or SRY, instead, it relies on androgens derived from the Leydig cells. Leydig cells do not express SRY, indicating that a crosstalk must be present between the SRY-positive Sertoli and Leydig cells to ensure normal androgen production. Recent advancement of genetic and genomic approaches has unveiled the molecular pathways for differentiation of Sertoli cells and Leydig cells as well as development of the Wolffian duct.

引用

页码：223 / 228

页数：6

共 76 条

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