Osteoinductive bone graft substitutes

被引：41

作者：

Ludwig, SC ^{[1
]}

Kowalski, JM ^{[1
]}

Boden, SD ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Emory Spine Ctr, Atlanta, GA USA

来源：

EUROPEAN SPINE JOURNAL | 2000年 / 9卷 / Suppl 1期

关键词：

bone morphogenetic protein; gene therapy; bone graft substitute; spine fusion;

D O I：

10.1007/PL00008317

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This review will summarize the major efforts currently underway to develop osteoinductive bone graft substitutes for minimally invasive spine fusions. The primary categories of substitute include purl fled bone growth factors, recombinant bone growth factors, and growth factors delivered by gene therapy approaches. Clinical trials are underway for the purified and recombinant bone growth factors and pre-clinical studies have yielded promising results for a variety of gene therapy techniques for generating bone.

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页码：S119 / S125

页数：7

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