Commemorating the 1913 Michaelis-Mentenpaper Die Kinetik der Invertinwirkung: three perspectives

被引:53
作者
Deichmann, Ute [1 ]
Schuster, Stefan [2 ]
Mazat, Jean-Pierre [3 ,4 ]
Cornish-Bowden, Athel [5 ,6 ]
机构
[1] Ben Gurion Univ Negev, Jacques Loeb Ctr Hist & Philosophy Life Sci, IL-84105 Beer Sheva, Israel
[2] Univ Jena, Dept Bioinformat, D-07745 Jena, Germany
[3] CNRS UMR 5095, Bordeaux, France
[4] Univ Bordeaux, Bordeaux, France
[5] CNRS, Unite Bioenerget & Ingn Prot, Inst Microbiol Mediterranee, F-75700 Paris, France
[6] Aix Marseille Univ, F-13402 Marseille 20, France
关键词
enzyme kinetics; Henri; history and philosophy; initial rate; Menten; Michaelis; steady state; HYDROGEN-ION CONCENTRATION; ABSORPTION-SPECTRUM; LEONOR-MICHAELIS; ENZYME; SUBSTANCES; ACTIVATION; REDUCTION; INVERSION; MOLECULE; COMPLEX;
D O I
10.1111/febs.12598
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Methods and equations for analysing the kinetics of enzyme-catalysed reactions were developed at the beginning of the 20th century in two centres in particular; in Paris, by Victor Henri, and, in Berlin, by Leonor Michaelis and Maud Menten. Henri made a detailed analysis of the work in this area that had preceded him, and arrived at a correct equation for the initial rate of reaction. However, his approach was open to the important objection that he took no account of the hydrogen-ion concentration (a subject largely undeveloped in his time). In addition, although he wrote down an expression for the initial rate of reaction and described the hyperbolic form of its dependence on the substrate concentration, he did not appreciate the great advantages that would come from analysis in terms of initial rates rather than time courses. Michaelis and Menten not only placed Henri's analysis on a firm experimental foundation, but also defined the experimental protocol that remains standard today. Here, we review this development, and discuss other scientific contributions of these individuals. The three parts have different authors, as indicated, and do not necessarily agree on all details, in particular about the relative importance of the contributions of Michaelis and Menten on the one hand and of Henri on the other. Rather than force the review into an unrealistic consensus, we consider it appropriate to leave the disagreements visible.
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页码:435 / 463
页数:29
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