Sensory testing in the assessment of laryngeal sensation in patients with amyotrophic lateral sclerosis

被引:36
作者
Amin, Milan R.
Harris, Donna
Cassel, Stacy Gallese
Grimes, Eric
Heiman-Patterson, Terry
机构
[1] Drexel Univ, Coll Med, Voice Ctr, Philadelphia, PA USA
[2] Drexel Univ, Dept Otolaryngol, Philadelphia, PA USA
[3] Drexel Univ, Dept Neurol, MDA ALS Ctr Hope, Philadelphia, PA USA
[4] Temple Univ, Dept Otolaryngol, Philadelphia, PA USA
[5] Med Coll Penn & Hahnemann Univ, Dept Speech Pathol, Philadelphia, PA 19102 USA
关键词
amyotrophic lateral sclerosis; aspiration pneumonia; deglutition; FEESST; larynx; sensory dysfunction;
D O I
10.1177/000348940611500707
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Objectives: Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease of unknown cause. Mortality in the population is frequently due to aspiration pneumonia. Although typically considered to be a disorder limited to motor neuron involvement, some investigators have indicated that decreased sensory function in ALS patients additionally contributes to the disease process. The objective of this study was to evaluate laryngopharyngeal sensation in the ALS population in order to quantify the range of sensory deficits and correlate any abnormalities with demographic data to determine which patients are at risk of having sensory deficits. Methods: We examined the sensation of the larynx in 22 patients with ALS to determine whether a sensory deficit was present. After completion of a dysphagia questionnaire and medical history, patients underwent flexible endoscopic evaluation of swallowing with sensory testing (FEESST) to evaluate sensory function. Threshold values were determined and recorded for initiation of the adductor reflex. Results: The results of the sensory and swallowing function assessments performed on 22 patients demonstrate abnormal sensation in 54.5% of the tested population. Asymmetric findings were noted in 75% of these patients. There was no correlation noted between the presence of sensory deficits and the severity or duration of the disease. Conclusions: Progressive dysphagia in the ALS population has typically been attributed to muscle weakness. This study points to the presence of sensory deficits in the larynx, which can further affect proper swallowing function.
引用
收藏
页码:528 / 534
页数:7
相关论文
共 13 条
[1]   Endoscopic evaluation of swallowing as an alternative to 24-hour pH monitoring for diagnosis of extraesophageal reflux [J].
Aviv, JE ;
Parides, M ;
Fellowes, J ;
Close, LG .
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, 2000, 109 (10) :25-27
[2]   Fiberoptic endoscopic evaluation of swallowing with sensory testing (FEESST) in healthy controls [J].
Aviv, JE ;
Kim, T ;
Thomson, JE ;
Sunshine, S ;
Kaplan, S ;
Close, LG .
DYSPHAGIA, 1998, 13 (02) :87-92
[3]   Validity and reliability of the reflux symptom index (RSI) [J].
Belafsky, PC ;
Postma, GN ;
Koufman, JA .
JOURNAL OF VOICE, 2002, 16 (02) :274-277
[4]  
Brooks BR, 1996, ARCH NEUROL-CHICAGO, V53, P141
[5]   Pathophysiological mechanisms of oropharyngeal dysphagia in amyotrophic lateral sclerosis [J].
Ertekin, C ;
Aydogdu, I ;
Yüceyar, N ;
Kiylioglu, N ;
Tarlaci, S ;
Uludag, B .
BRAIN, 2000, 123 :125-140
[6]  
GEORGESCO M, 1994, REV NEUROL, V150, P292
[7]   Symptomatic treatment of respiratory and nutritional failure in amyotrophic lateral sclerosis [J].
Hardiman, O .
JOURNAL OF NEUROLOGY, 2000, 247 (04) :245-251
[8]   MORPHOMETRIC COMPARISON OF THE VULNERABILITY OF PERIPHERAL MOTOR AND SENSORY NEURONS IN AMYOTROPHIC LATERAL SCLEROSIS [J].
KAWAMURA, Y ;
DYCK, PJ ;
SHIMONO, M ;
OKAZAKI, H ;
TATEISHI, J ;
DOI, H .
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1981, 40 (06) :667-675
[9]   Prominent sensory and autonomic disturbances in familial amyotrophic lateral sclerosis with a Gly93Ser mutation in the SOD1 gene [J].
Kawata, A ;
Kato, S ;
Hayashi, H ;
Hirai, S .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 1997, 153 (01) :82-85
[10]   Oropharyngeal dysphagia in amyotrophic lateral sclerosis: neurological and dysphagia specific rating scales [J].
Kidney, D ;
Alexander, M ;
Corr, B ;
O'Toole, O ;
Hardiman, O .
AMYOTROPHIC LATERAL SCLEROSIS AND OTHER MOTOR NEURON DISORDERS, 2004, 5 (03) :150-153