The Nogo signaling pathway for regeneration block

被引:174
作者
He, ZG [1 ]
Koprivica, V
机构
[1] Harvard Univ, Sch Med, Childrens Hosp, Div Neurosci, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Program Neurosci, Boston, MA 02116 USA
关键词
axon regeneration; Nogo-A; myelin-associated glycoprotein; oligodendrocyte myelin glycoprotein; chondroitin sulfate proteoglycan; p75; RhoA;
D O I
10.1146/annurev.neuro.27.070203.144340
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
A hostile environment and decreased regenerative capacity may contribute to the failure of axon regeneration in the adult central nervous system. Recent studies leading to the identification of several myelin-associated inhibitors and their signaling molecules provide opportunitities to assess the contribution of these inhibitory molecules in restricting axon regeneration. These findings may ultimately allow for the development of strategies to alleviate the inhibitory effects of such molecules in an effort to encourage axon regeneration after spinal cord and brain injury.
引用
收藏
页码:341 / 368
页数:30
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