Airway eicosanoids in acute severe respiratory syncytial virus bronchiolitis

被引：42

作者：

Sznajer, Y

Westcott, JY

Wenzel, SE

Mazer, B

Tucci, M

Toledano, BJ

机构：

[1] Univ Montreal, Hop St Justine, Pediat Intens Care Unit, Montreal, PQ H3T 1C5, Canada

[2] McGill Univ, Meakins Christie Lab, Montreal, PQ, Canada

[3] Natl Jewish Med & Res Ctr, Dept Med, Denver, CO USA

来源：

JOURNAL OF PEDIATRICS | 2004年 / 145卷 / 01期

关键词：

D O I：

10.1016/j.jpeds.2004.03.049

中图分类号：

R72 [儿科学];

学科分类号：

100202 [儿科学];

摘要：

We prospectively studied the levels of eicosanoids in intubated patients with severe bronchiolitis and compared them to electively intubated non-infected infants. LeukotrieneE(4)(LTE4), leukotrieneB(4) (LTB4), and prostaglandinE(2) (PGE(2)) levels were significantly increased (P < .01) from endotracheal (ET) aspirates of infants with bronchiolitis compared with controls, as were urinary LTE4 levels (P < .001). We conclude that eicosanoids are increased in the tracheal aspirates and urine of children with bronchiolitis.

引用

页码：115 / 118

页数：4

共 14 条

[1]

The role and contribution of leukotrienes in asthma [J].