A biocompatible method of decorporation: Bisphosphonate-modified magnetite nanoparticles to remove uranyl ions from blood

被引：207

作者：

Wang, Ling ^{[1
]}

Yang, Zhimou ^{[1
]}

Gao, Jinhao ^{[1
]}

Xu, Keming ^{[1
]}

Gu, Hongwei ^{[1
]}

Zhang, Bei ^{[1
]}

Zhang, Xixiang ^{[1
]}

Xu, Bing ^{[1
]}

机构：

[1] Hong Kong Univ Sci & Technol, Dept Chem & Phys, Hong Kong, Hong Kong, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 41期

关键词：

D O I：

10.1021/ja0651355

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report on the use of bisphosphonate to functionalize Fe3O4 magnetic nanoparticles via dopamine (DA) linkage. Using tetraethyl-3-aminopropane-1,1-bisphosphonate (BP) as the functional molecule, we created a system with an Fe3O4-DA-BP nanostructure, which possesses high specificity for removing uranyl ions from water or blood. This work demonstrates that magnetic nanoparticles, combined with specific receptor-ligand interactions, promise a sensitive and rapid platform for the detection, recovery, and decorporation of metal toxins from biological environment. Copyright © 2006 American Chemical Society.

引用

页码：13358 / 13359

页数：2

共 36 条

[1]

BRADL HB, 2005, HEAVYMETALS ENV ORIG

[2] Gold-coated iron nanoparticles for biomedical applications [J].

Chen, M ;

Yamamuro, S ;

Farrell, D ;

Majetich, SA .

JOURNAL OF APPLIED PHYSICS, 2003, 93 (10) :7551-7553

[3] Synthesis, self-assembly, and magnetic properties of FexCoyPt100-x-y nanoparticles [J].

Chen, M ;

Nikles, DE .

NANO LETTERS, 2002, 2 (03) :211-214

[4] Laser-assisted catalytic growth of single crystal GaN nanowires [J].

Duan, XF ;

Lieber, CM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (01) :188-189

[5]

Fergusson JE., 1990, HEAVY ELEMENTS CHEM

[6] Chelating agents used for plutonium and uranium removal in radiation emergency medicine [J].

Fukuda, S .

CURRENT MEDICINAL CHEMISTRY, 2005, 12 (23) :2765-2770

[7] Dendrimer-coated magnetic particles for radionuclide separation [J].

Grüttner, C ;

Böhmer, V ;

Casnati, A ;

Dozol, JF ;

Reinhoudt, DN ;

Reinoso-Garcia, MM ;

Rudershausen, S ;

Teller, J ;

Ungaro, R ;

Verboom, W ;

Wang, PS .

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 2005, 293 (01) :559-566

[8] Biofunctional magnetic nanoparticles for protein separation and pathogen detection [J].

Gu, HW ;

Xu, KM ;

Xu, CJ ;

Xu, B .

CHEMICAL COMMUNICATIONS, 2006, (09) :941-949

[9] Facile one-pot synthesis of bifunctional heterodimers of nanoparticles: A conjugate of quantum dot and magnetic nanoparticles [J].

Gu, HW ;

Zheng, RK ;

Zhang, XX ;

Xu, B .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (18) :5664-5665

[10] Using biofunctional magnetic nanoparticles to capture vancomycin-resistant enterococci and other gram-positive bacteria at ultralow concentration [J].

Gu, HW ;

Ho, PL ;

Tsang, KWT ;

Wang, L ;

Xu, B .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (51) :15702-15703

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