Activity of tigecycline (GAR-936) against Acinetobacter baumannii strains, including those resistant to imipenem

被引：133

作者：

Pachón-Ibáñez, ME

Jiménez-Mejías, ME

Pichardo, C

Llanos, AC

Pachón, J

机构：

[1] Hosp Univ Virgen Rocio, Infect Dis Serv, Seville, Spain

[2] Hosp Univ Virgen Rocio, Microbiol Serv, Seville, Spain

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2004年 / 48卷 / 11期

关键词：

D O I：

10.1128/AAC.48.11.4479-4481.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We determined the in vitro activities of tigecycline and imipenem against 49 isolates of Acinetobacter baumannii, including those resistant to imipenem. The MIC at which 50% of the isolates were inhibited (MlC(50)) and the MIC90 for tigecycline and imipenem were 2 and 2 mg/liter and 32 and 128 mg/liter, respectively, with 92 and 20%, respectively, of the strains being susceptible. Tigecycline did not show bactericidal activity in the time-kill studies (n = 9 strains). Imipenem showed bactericidal activity against seven out of nine strains. These in vitro results show that tigecycline has good in vitro bacteriostatic activity against A. baumannii, including strains resistant to imipenem.

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页码：4479 / 4481

页数：3

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