Synthesis and stability study of the new pentammonio lipid pcTG90, a gene transfer agent

被引：9

作者：

Nazih, A

Cordier, Y

Bischoff, R

Kolbe, HVJ

Heissler, D

机构：

[1] Transgene SA, F-67082 Strasbourg, France

[2] Univ Strasbourg, F-67008 Strasbourg, France

[3] CNRS, Inst Chim, F-67008 Strasbourg, France

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 46期

关键词：

polyamines; amphiphilic compounds;

D O I：

10.1016/S0040-4039(99)01673-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The cationic lipid pcTG90 has been prepared from (S)-1-aminopropane-2,3-diol by N-acylation with N-protected 18-amino-3,7,11,15-tetraazaoctadecanoic acid and O-acylation with oleic acid. The former acid could be obtained from 1,3-propanediamine via tetraprotected caldopentamine. The stability of the cationic lipid in HEPES buffer has been studied. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：8089 / 8091

页数：3

共 8 条

[1]

BERGERON RJ, 1984, SYNTHESIS-STUTTGART, P782

[2] Homologation of polyamines in the synthesis of lipo-spermine conjugates and related lipoplexes [J].