Neurotrophin signaling:: many exciting surprises!

被引：279

作者：

Arevalo, J. C. ^{[1
]}

Wu, S. H. ^{[1
]}

机构：

[1] NYU, Sch Med, Skirball Inst Biomol Med, New York, NY 10016 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2006年 / 63卷 / 13期

关键词：

neurotrophin; Trk; p75(NTR); signaling; neuron; survival;

D O I：

10.1007/s00018-006-6010-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Neurotrophins are growth factors implicated in the development and maintenance of different neuronal populations in the nervous system. Neurotrophins bind to two sets of receptors, Trk receptor tyrosine kinases and the p75(NTR) receptor, to activate several different signaling pathways that mediate various biological functions. While Trk receptor activation has been well-studied and triggers the well-characterized Ras/Rap-MAPK, PI3K-Akt, and PLC gamma-PKC cascades, p75(NTR) signaling is more complex, and its in vivo significance has not yet been completely determined. In the last few years, p75(NTR) has received much attention mainly due to recent findings describing pro-neurotrophins as new ligands for the receptor and the ability of the receptor to form different complexes with other transmembrane proteins. This review will update the neurotrophin signaling pathways known for Trk receptors to include newly identified Trk-interacting molecules and will address surprising new findings that suggest a role for p75(NTR) in different receptor complexes and functions.

引用

页码：1523 / 1537

页数：15

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