Immediate recovery from spinal cord injury through molecular repair of nerve membranes with polyethylene glycol

被引：94

作者：

Borgens, RB ^{[1
]}

Shi, R ^{[1
]}

机构：

[1] Purdue Univ, Dept Basic Med Sci, Ctr Paralysis Res, Sch Vet Med, W Lafayette, IN 47907 USA

来源：

FASEB JOURNAL | 2000年 / 14卷 / 01期

关键词：

nerve fusion; nerve repair; neurotrauma;

D O I：

10.1096/fasebj.14.1.27

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A brief application of the hydrophilic polymer polyethylene glycol (PEG) swiftly repairs nerve membrane damage associated with severe spinal cord injury in adult guinea pigs. A 2 min application of PEG to a standardized compression injury to the cord immediately reversed the loss of nerve impulse conduction through the injury in all treated animals while nerve impulse conduction remained absent in all sham-treated guinea pigs. Physiological recovery was associated with a significant recovery of a quantifiable spinal cord dependent behavior in only PEG-treated animals. The application of PEG could be delayed for similar to 8 h without adversely affecting physiological and behavioral recovery which continued to improve for up to 1 month after PEG treatment.-Borgens, R. B., Shi, R. Immediate recovery from spinal cord injury through molecular repair of nerve membranes with polyethylene glycol.

引用

页码：27 / 35

页数：9

共 39 条

[1]

AHKONG QF, 1987, J CELL SCI, V88, P389

[2]

ALDEWINCKEL TL, 1982, BIOCHIM BIOPHYS ACTA, V689, P548

[3]

ASANO T, 1995, J NEUROTRAUM, V12, P993

[4]

Blight A R, 1985, Cent Nerv Syst Trauma, V2, P299

[5] MORPHOMETRIC ANALYSIS OF A MODEL OF SPINAL-CORD INJURY IN GUINEA-PIGS, WITH BEHAVIORAL EVIDENCE OF DELAYED SECONDARY PATHOLOGY [J].

BLIGHT, AR .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1991, 103 (02) :156-171

[6]

BLIGHT AR, 1993, ADV NEUROL, V59, P91

[7]

BLIGHT AR, 1990, J COMP NEUOL, V60, P446

[8] An imposed oscillating electrical field improves the recovery of function in neurologically complete paraplegic dogs [J].

Borgens, RB ;

Toombs, JP ;

Breur, G ;

Widmer, WR ;

Waters, D ;

Harbath, AM ;

March, P ;

Adams, LG .

JOURNAL OF NEUROTRAUMA, 1999, 16 (07) :639-657

[9] AXONAL REGENERATION IN SPINAL-CORD INJURY - A PERSPECTIVE AND NEW TECHNIQUE [J].

BORGENS, RB ;

BLIGHT, AR ;

MURPHY, DJ .

JOURNAL OF COMPARATIVE NEUROLOGY, 1986, 250 (02) :157-167

[10] BEHAVIORAL RECOVERY INDUCED BY APPLIED ELECTRIC-FIELDS AFTER SPINAL-CORD HEMISECTION IN GUINEA-PIG [J].

BORGENS, RB ;

BLIGHT, AR ;

MCGINNIS, ME .

SCIENCE, 1987, 238 (4825) :366-369

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