Runx1, c-Myb, and C/EBPα couple differentiation to proliferation or growth arrest during hermatopoiesis

被引：27

作者：

Friedman, AD ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Pediat Oncol, Baltimore, MD 21231 USA

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2002年 / 86卷 / 04期

关键词：

Runxl; C/EBP alpha; c-Myb; hematopoiesis; cell cycle;

D O I：

10.1002/jcb.10271

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Immature hematopoietic precursors proliferate as they differentiate, whereas terminal differentiation is associated with cell cycle arrest. Stem cell lineage commitment and subseqent maturation is regulated predominantly by transcription factors. Runx1 and c-Myb act in early stage hematopoietic cells to both stimulate proliferation and differentiation, whereas C/EBPalpha, and perhaps other C/EBP family members, block progression from G1 to S and induce terminal maturation. Coupling of differentiation to either proliferation or growth arrest by transcription factors is likely an important regulatory mechanism in multiple developmental systems. (C) 2002 Wiley-Liss, Inc.

引用

页码：624 / 629

页数：6

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