Spongiform encephalopathies - B lymphocytes and neuroinvasion

被引：1133

作者：

Brown, P

机构：

[1] the Laboratory of CNS Studies,

[2] National Institute of Neurological Disorders and Stroke,undefined

[3] National Institutes of Health,undefined

来源：

NATURE | 1997年 / 390卷 / 6661期

关键词：

D O I：

10.1038/37733

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

How does consumption of meat products infected with bovine spongiform encephalopathy (BSE) lead to development of Creutzfeldt-Jakob disease (CJD)? Studies of the brain, spleen and marrow of many immunodeficient mouse lines indicate that differentiated B lymphocytes are important for neuroinvasion. This discovery has implications for therapies against CJD, and also for the broader public-health issue of screening blood products against possible infection.

引用

页码：662 / 663

页数：2