Cartilage oligomeric matrix protein and its binding partners in the cartilage extracellular matrix: Interaction, regulation and role in chondrogenesis

被引：130

作者：

Acharya, Chitrangada ^{[1
]}

Yik, Jasper H. N. ^{[1
]}

Kishore, Ashleen ^{[1
]}

Victoria Van Dinh ^{[1
]}

Di Cesare, Paul E. ^{[2
]}

Haudenschild, Dominik R. ^{[1
]}

机构：

[1] Univ Calif Davis, Med Ctr, Lawrence J Ellison Musculoskeletal Res Ctr, Dept Orthopaed Surg, Sacramento, CA 95817 USA

[2] New York Hosp Queens, Dept Orthopaed & Rehabil, New York, NY 11355 USA

来源：

MATRIX BIOLOGY | 2014年 / 37卷

关键词：

Cartilage oligomeric matrix protein; Extracellular matrix; Receptors; Proteases; Growth factors; Complement system; MULTIPLE EPIPHYSEAL DYSPLASIA; HUMAN ARTICULAR-CARTILAGE; 5-STRANDED COILED-COIL; MESENCHYMAL STEM-CELLS; COLLAGEN-IX; CRYSTAL-STRUCTURE; CAUSE PSEUDOACHONDROPLASIA; OSTEOARTHRITIC CARTILAGE; INDEPENDENT MECHANISMS; ENDOPLASMIC-RETICULUM;

D O I：

10.1016/j.matbio.2014.06.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Thrombospondins (TSPs) are widely known as a family of five calcium-binding matricellular proteins. While these proteins belong to the same family, they are encoded by different genes, regulate different cellular functions and are localized to specific regions of the body. TSP-5 or Cartilage Oligomeric Matrix Protein (COMP) is the only TSP that has been associated with skeletal disorders in humans, including pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). The pentameric structure of COMP, the evidence that it interacts with multiple cellular proteins, and the recent reports of COMP acting as a 'lattice' to present growth factors to cells, inspired this review of COMP and its interacting partners. In our review, we have compiled the interactions of COMP with other proteins in the cartilage extracellular matrix and summarized their importance in maintaining the structural integrity of cartilage as well as in regulating cellular functions. (C) 2014 Elsevier B.V.

引用

页码：102 / 111

页数：10

共 99 条

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Thrombospondins: Multifunctional regulators of cell interactions [J].