A tumor responsive self healing prodrug hydrogel enables synergistic action of doxorubicin and miltefosine for focal combination chemotherapy

被引：23

作者：

Balakrishnan, Biji ^{[1
]}

Joshi, Nitin ^{[1
]}

Thorat, Ketan ^{[1
]}

Kaur, Shahdeep ^{[1
]}

Chandan, Rajeet ^{[1
]}

Banerjee, Rinti ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Biosci & Bioengn, Nanomed Lab, Mumbai 400076, Maharashtra, India

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2019年 / 7卷 / 18期

关键词：

NEGATIVE BREAST-CANCER; PACLITAXEL; RECURRENCE; CHITOSAN; RELEASE; CELLS; TRIAL;

D O I：

10.1039/c9tb00454h

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

082905 [生物质能源与材料]; 100103 [病原生物学];

摘要：

Targeted therapy that facilitates the on-site, on-demand action of drug combinations is a promising approach for combination chemotherapy. In situ gelling hydrogels were prepared using biopolymers with in-built imine and borate diol ester linkages to render pH and glucose responsiveness, respectively to achieve a triggered release of doxorubicin in tumor milieu. Doxorubicin prodrug hydrogel doped with miltefosine demonstrated a synergistic effect on inhibition of drug resistant MDA-MB 231 human breast cancer cells, suitable for focal combination chemotherapy.

引用

页码：2920 / 2925

页数：6

共 37 条

[1]

BACHUR NR, 1971, J PHARMACOL EXP THER, V177, P567

[2]

Self-cross-linking biopolymers as injectable in situ forming biodegradable scaffolds [J].

Balakrishnan, B ;

Jayakrishnan, A .

BIOMATERIALS, 2005, 26 (18) :3941-3951

[3]

Borate aided Schiff's base formation yields in situ gelling hydrogels for cartilage regeneration [J].

Balakrishnan, Biji ;

Joshi, Nitin ;

Banerjee, Rinti .

JOURNAL OF MATERIALS CHEMISTRY B, 2013, 1 (41) :5564-5577

[4]

Triple-negative breast cancer: disease entity or title of convenience? [J].

Carey, Lisa ;

Winer, Eric ;

Viale, Giuseppe ;

Cameron, David ;

Gianni, Luca .

NATURE REVIEWS CLINICAL ONCOLOGY, 2010, 7 (12) :683-692

[5]

A Reloadable Self-Healing Hydrogel Enabling Diffusive Transport of C-Dots Across Gel-Gel Interface for Scavenging Reactive Oxygen Species [J].

Chen, Jing ;

Li, Shuya ;

Zhang, Ye ;

Wang, Wei ;

Zhang, Xiang ;

Zhao, Yangyang ;

Wang, Yucai ;

Bi, Hong .

ADVANCED HEALTHCARE MATERIALS, 2017, 6 (21)

[6]

Injectable poly(organophosphazene)-camptothecin conjugate hydrogels: Synthesis, characterization, and antitumor activities [J].

Cho, Jung-Kyo ;

Chun, ChanJu ;

Kuh, Hyo-Jeong ;

Song, Soo-Chang .

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2012, 81 (03) :582-590

[7]

Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis [J].

Dorlo, Thomas P. C. ;

Balasegaram, Manica ;

Beijnen, Jos H. ;

de Vries, Peter J. .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2012, 67 (11) :2576-2597

[8]

Transdermal photopolymerization for minimally invasive implantation [J].

Elisseeff, J ;

Anseth, K ;

Sims, D ;

McIntosh, W ;

Randolph, M ;

Langer, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (06) :3104-3107

[9]

Acidity Generated by the Tumor Microenvironment Drives Local Invasion [J].

Estrella, Veronica ;

Chen, Tingan ;

Lloyd, Mark ;

Wojtkowiak, Jonathan ;

Cornnell, Heather H. ;

Ibrahim-Hashim, Arig ;

Bailey, Kate ;

Balagurunathan, Yoganand ;

Rothberg, Jennifer M. ;

Sloane, Bonnie F. ;

Johnson, Joseph ;

Gatenby, Robert A. ;

Gillies, Robert J. .

CANCER RESEARCH, 2013, 73 (05) :1524-1535

[10]

Fukumura D, 2001, CANCER RES, V61, P6020

← 1 2 3 4 →