Poor Vitamin D Status Is Prospectively Associated with Greater Muscle Mass Loss in Middle-Aged and Elderly Chinese Individuals

被引:42
作者
Liu, Gang [1 ]
Lu, Ling [1 ]
Sun, Qi [2 ,3 ,4 ]
Ye, Xingwang [1 ]
Sun, Liang [1 ]
Liu, Xin [1 ]
Zong, Geng [1 ]
Jin, Qianlu [1 ]
Li, Huaixing [1 ]
Lin, Xu [1 ]
机构
[1] Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci,Key Lab Nutr & Metab, Shanghai, Peoples R China
[2] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA
[3] Brigham & Womens Hosp, Dept Med, Channing Div, Med Network, Boston, MA 02115 USA
[4] Harvard Univ, Sch Med, Boston, MA USA
基金
中国国家自然科学基金; 中国博士后科学基金;
关键词
25-hydroxyvitamin D; Cohort study; Dual-energy x-ray absorptiometry; Muscle mass; Inflammation; BONE-MINERAL DENSITY; FAT-FREE MASS; 25-HYDROXYVITAMIN D CONCENTRATION; KOREA NATIONAL-HEALTH; METABOLIC SYNDROME; D SUPPLEMENTATION; D DEFICIENCY; PARATHYROID-HORMONE; BODY-COMPOSITION; D INSUFFICIENCY;
D O I
10.1016/j.jand.2014.05.012
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 [营养与食品卫生学];
摘要
Background Poor vitamin D status can increase age-related muscle mass loss. However, existing prospective evidence is limited and controversial. Objective This study aimed to investigate the association of plasma 25-hydroxyvitamin D [25(OH)D] with muscle mass loss in middle-aged and elderly Chinese individuals over 6 years. Design We conducted a prospective cohort study. Participants/setting This community-based study included 568 men and women aged 50 to 70 years at baseline. Main outcomes measures Baseline plasma concentrations of 25(OH)D and biomarkers of liver and kidney functions and inflammation were measured. Body composition was assessed at baseline and 6-year follow-up by dual-energy x-ray absorptiometry. Appendicular skeletal muscle mass (ASMM) and trunk lean mass were calculated and total body lean mass was defined as an overall measure of total nonfat and nonbone tissues. Statistical analyses performed Descriptive statistics and multiple linear regression were applied. Results The 6-year loss of ASMM was 1.14 kg (5.3%) in men and 0.47 kg (3.1%) in women (all P values <0.001). Compared with the highest 25(OH)D tertile, participants in the lowest tertile had significantly more absolute loss of ASMM (-1.21 vs -1.00 kg; P for trend=0.024) after multivariate adjustments for conventional confounders, as well as protein intake. The association persisted after additional adjustment of bone mineral density and inflammatory markers (P for trend=0.017). No significant associations were detected between 25(OH)D and absolute loss of trunk lean mass or total body lean mass. Conclusions Lower 25(OH)D concentrations were prospectively associated with greater ASMM loss in middle-aged and elderly Chinese individuals independent of bone mineral density, inflammation, diet, and other risk factors.
引用
收藏
页码:1544 / 1551
页数:8
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