RNA folding at elementary step resolution

被引：213

作者：

Flamm, C

Fontana, W

Hofacker, IL

Schuster, P

机构：

[1] Univ Vienna, Inst Theoret Chem & Mol Strukt Biol, A-1090 Vienna, Austria

[2] Santa Fe Inst, Santa Fe, NM 87501 USA

来源：

RNA | 2000年 / 6卷 / 03期

关键词：

conformational spaces; foldability; RNA folding kinetics; RNA secondary structure;

D O I：

10.1017/S1355838200992161

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We study the stochastic folding kinetics of RNA sequences into secondary structures with a new algorithm based on the formation, dissociation, and the shifting of individual base pairs. We discuss folding mechanisms and the correlation between the barrier structure of the conformational landscape and the folding kinetics for a number of examples based on artificial and natural sequences, including the influence of base modification in tRNAs.

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页码：325 / 338

页数：14

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