Effect of arsenic (AsIII) on glutathione-dependent enzymes in liver and kidney of the freshwater fish channa punctatus

被引：40

作者：

Allen, T

Rana, SVS ^{[1
]}

机构：

[1] Ch Charan Singh Univ, Dept Environm Sci, Meerut 250004, Uttar Pradesh, India

[2] Ch Charan Singh Univ, Dept Zool, Toxicol Lab, Meerut 250004, Uttar Pradesh, India

来源：

BIOLOGICAL TRACE ELEMENT RESEARCH | 2004年 / 100卷 / 01期

关键词：

arsenic; liver; kidney; fish; phase II enzymes;

D O I：

10.1385/BTER:100:1:039

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The possible role of glutathione-dependent enzymes in the liver and kidney of the freshwater fish Channa punctatus has been studied after exposure to arsenic trioxide for different durations. Activities of glutathione-S-transferases, glutathione peroxidase, glutathione reductase, and catalase decreased in the liver and kidney as a result of the initial increase in arsenic concentration in the liver and kidney. However, during longer exposures, a decline in arsenic concentration corresponded with improved enzyme activity. Because arsenic manifests its toxicity by inducing oxidative stress, the antioxidant enzymes, especially the glutathione-dependent enzymes, play a protective role in arsenic toxicity.

引用

页码：39 / 48

页数：10

共 33 条

[1] Resistance to oxidative stress in a freshwater fish Channa punctatus after exposure to inorganic arsenic [J].