Role of gamma interferon and interleukin-4 in host defense against the human filarial parasite Brugia malayi

被引：61

作者：

Babu, S

Ganley, LM

Klei, TR

Shultz, LD

Rajan, TV ^{[1
]}

机构：

[1] Univ Connecticut, Ctr Hlth, Dept Pathol, Farmington, CT 06030 USA

[2] Louisiana State Univ, Dept Vet Microbiol & Parasitol, Baton Rouge, LA 70803 USA

[3] Jackson Lab, Bar Harbor, ME 04609 USA

来源：

INFECTION AND IMMUNITY | 2000年 / 68卷 / 05期

关键词：

D O I：

10.1128/IAI.68.5.3034-3035.2000

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have investigated the roles of gamma interferon (IFN-gamma) and interleukin-1 (IL-4) in host defense against Brugia malayi. Our data suggest that the lack of either IFN-gamma or IL-4 prolongs the time required to achieve sterile immunity, suggesting that bath canonical type 1 and type 2 responses are involved in the clearance of infection.

引用

页码：3034 / 3035

页数：2