Herpesvirus Saimiri encodes a functional homolog of the human bcl-2 oncogene

被引：113

作者：

Nava, VE

Cheng, EHY

Veliuona, M

Zou, SF

Clem, RJ

Mayer, ML

Hardwick, JM

机构：

[1] JOHNS HOPKINS SCH PUBL HLTH,DEPT MOL MICROBIOL & IMMUNOL,BALTIMORE,MD 21205

[2] JOHNS HOPKINS SCH MED,DEPT PHARMACOL,BALTIMORE,MD 21205

[3] JOHNS HOPKINS SCH MED,DEPT MOL SCI,BALTIMORE,MD 21205

[4] JOHNS HOPKINS SCH MED,DEPT NEUROL,BALTIMORE,MD 21205

来源：

JOURNAL OF VIROLOGY | 1997年 / 71卷 / 05期

关键词：

D O I：

10.1128/JVI.71.5.4118-4122.1997

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Here we demonstrate that open reading frame 16 (ORF16) of the oncogenic herpesvirus saimiri protects cells from heterologous virus-induced apoptosis. The BH1 and BH2 homology domains are highly conserved in ORF16, and ORF16 heterodimerizes with Bcl-2 family members Bar and Bak. However, ORF16 lacks the core sequence of the conserved BH3 homology domain, suggesting that this region is not essential for anti-apoptotic activity. Conservation of a functional bcl-2 homolog among gammaherpesviruses suggests that inhibition of programmed cell death is important in the biology of these viruses.

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页码：4118 / 4122

页数：5

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