Herpesvirus Saimiri encodes a functional homolog of the human bcl-2 oncogene

被引:113
作者
Nava, VE
Cheng, EHY
Veliuona, M
Zou, SF
Clem, RJ
Mayer, ML
Hardwick, JM
机构
[1] JOHNS HOPKINS SCH PUBL HLTH,DEPT MOL MICROBIOL & IMMUNOL,BALTIMORE,MD 21205
[2] JOHNS HOPKINS SCH MED,DEPT PHARMACOL,BALTIMORE,MD 21205
[3] JOHNS HOPKINS SCH MED,DEPT MOL SCI,BALTIMORE,MD 21205
[4] JOHNS HOPKINS SCH MED,DEPT NEUROL,BALTIMORE,MD 21205
关键词
D O I
10.1128/JVI.71.5.4118-4122.1997
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Here we demonstrate that open reading frame 16 (ORF16) of the oncogenic herpesvirus saimiri protects cells from heterologous virus-induced apoptosis. The BH1 and BH2 homology domains are highly conserved in ORF16, and ORF16 heterodimerizes with Bcl-2 family members Bar and Bak. However, ORF16 lacks the core sequence of the conserved BH3 homology domain, suggesting that this region is not essential for anti-apoptotic activity. Conservation of a functional bcl-2 homolog among gammaherpesviruses suggests that inhibition of programmed cell death is important in the biology of these viruses.
引用
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页码:4118 / 4122
页数:5
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