Avoiding Unintended Toxicity

被引：6

作者：

Golde, Todd E. ^{[1
]}

Kukar, Thomas L. ^{[1
]}

机构：

[1] Mayo Clin, Coll Med, Dept Neurosci, Jacksonville, FL 32224 USA

来源：

SCIENCE | 2009年 / 324卷 / 5927期

关键词：

ALZHEIMERS-DISEASE; SECRETASE; APH-1;

D O I：

10.1126/science.1174267

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

引用

页码：603 / 604

页数：2

共 14 条

[1]

Aph-1, Pen-2, and nicastrin with presenilin generate an active γ-secretase complex [J].

De Strooper, B .

NEURON, 2003, 38 (01) :9-12

[2]

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain [J].

De Strooper, B ;

Annaert, W ;

Cupers, P ;

Saftig, P ;

Craessaerts, K ;

Mumm, JS ;

Schroeter, EH ;

Schrijvers, V ;

Wolfe, MS ;

Ray, WJ ;

Goate, A ;

Kopan, R .

NATURE, 1999, 398 (6727) :518-522

[3]

β-secretase as a therapeutic target for Alzheimer's disease [J].

Ghosh, Arun K. ;

Gemma, Sandra ;

Tang, Jordan .

NEUROTHERAPEUTICS, 2008, 5 (03) :399-408

[4]

Disease modifying therapy for AD? [J].

Golde, Todd E. .

JOURNAL OF NEUROCHEMISTRY, 2006, 99 (03) :689-707

[5]

AMYLOID BETA-PEPTIDE IS PRODUCED BY CULTURED-CELLS DURING NORMAL METABOLISM [J].

HAASS, C ;

SCHLOSSMACHER, MG ;

HUNG, AY ;

VIGOPELFREY, C ;

MELLON, A ;

OSTASZEWSKI, BL ;

LIEBERBURG, I ;

KOO, EH ;

SCHENK, D ;

TEPLOW, DB ;

SELKOE, DJ .

NATURE, 1992, 359 (6393) :322-325

[6]

Medicine - The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics [J].

Hardy, J ;

Selkoe, DJ .

SCIENCE, 2002, 297 (5580) :353-356

[7]

Substrate-targeting γ-secretase modulators [J].

Kukar, Thomas L. ;

Ladd, Thomas B. ;

Bann, Maralyssa A. ;

Fraering, Patrick C. ;

Narlawar, Rajeshwar ;

Maharvi, Ghulam M. ;

Healy, Brent ;

Chapman, Robert ;

Welzel, Alfred T. ;

Price, Robert W. ;

Moore, Brenda ;

Rangachari, Vijayaraghavan ;

Cusack, Bernadette ;

Eriksen, Jason ;

Jansen-West, Karen ;

Verbeeck, Christophe ;

Yager, Debra ;

Eckman, Christopher ;

Ye, Wenjuan ;

Sagi, Sarah ;

Cottrell, Barbara A. ;

Torpey, Justin ;

Rosenberry, Terrone L. ;

Fauq, Abdul ;

Wolfe, Michael S. ;

Schmidt, Boris ;

Walsh, Dominic M. ;

Koo, Edward H. ;

Golde, Todd E. .

NATURE, 2008, 453 (7197) :925-U62

[8]

Discovery of Begacestat, a Notch-1-Sparing γ-Secretase Inhibitor for the Treatment of Alzheimer's Disease [J].

Mayer, Scott C. ;

Kreft, Anthony F. ;

Harrison, Boyd ;

Abou-Gharbia, Magid ;

Antane, Madelene ;

Aschmies, Suzan ;

Atchison, Kevin ;

Chlenov, Michael ;

Cole, Derek C. ;

Comery, Thomas ;

Diamantidis, George ;

Ellingboe, John ;

Fan, Kristi ;

Galante, Rocco ;

Gonzales, Cathleen ;

Ho, Douglas M. ;

Hoke, Molly E. ;

Hu, Yun ;

Huryn, Donna ;

Jain, Uday ;

Jin, Mei ;

Kremer, Kenneth ;

Kubrak, Dennis ;

Lin, Melissa ;

Lu, Peimin ;

Magolda, Ron ;

Martone, Robert ;

Moore, William ;

Oganesian, Aram ;

Pangalos, Menelas N. ;

Porte, Alex ;

Reinhart, Peter ;

Resnick, Lynn ;

Riddell, David R. ;

Sonnenberg-Reines, June ;

Stock, Joseph R. ;

Sun, Shaiu-Ching ;

Wagner, Erik ;

Wang, Ting ;

Woller, Kevin ;

Xu, Zheng ;

Zaleska, Margaret M. ;

Zeldis, Joseph ;

Zhang, Minsheng ;

Zhou, Hua ;

Jacobsen, J. Steven .

JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (23) :7348-7351

[9]

γ-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia [J].

Real, Pedro J. ;

Tosello, Valeria ;

Palomero, Teresa ;

Castillo, Mireia ;

Hernando, Eva ;

de Stanchina, Elisa ;

Sulis, Maria Luisa ;

Barnes, Kelly ;

Sawai, Catherine ;

Homminga, Irene ;

Meijerink, Jules ;

Aifantis, Iannis ;

Basso, Giuseppe ;

Cordon-Cardo, Carlos ;

Ai, Walden ;

Ferrando, Adolfo .

NATURE MEDICINE, 2009, 15 (01) :50-58

[10]

Rational targeting of Notch signaling in cancer [J].

Rizzo, P. ;

Osipo, C. ;

Foreman, K. ;

Golde, T. ;

Osborne, B. ;

Miele, L. .

ONCOGENE, 2008, 27 (38) :5124-5131

← 1 2 →