Leukocyte adhesion molecule expression and T cell naive/memory status following isoproterenol infusion

被引:49
作者
Mills, PJ
Goebel, M
Rehman, J
Irwin, MR
Maisel, AS
机构
[1] Univ Calif San Diego, Med Ctr, Dept Psychiat, San Diego, CA 92103 USA
[2] VA Med Ctr, Dept Med, La Jolla, CA USA
关键词
lymphocytes; isoproterenol; neuroimmunology; CD62L; CD11a; CD54;
D O I
10.1016/S0165-5728(99)00180-0
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
This study examined adhesion molecules on peripheral leukocytes following a 30-min infusion of the beta-adrenergic agonist isoproterenol in 23 healthy subjects. In response to isoproterenol, the number of CD8(+)CD62L(-) T cells and both CD62L(+) and CD62L(-) natural killer (NK) (CD3(-)CD16(+)56(+)) cells increased markedly in circulation (p < 0.001). In addition, the surface density of CD62L was significantly lower on both CD8(+) and CD4(+) T cells (p < 0.001). Plasma levels of soluble CD62L remained unchanged, arguing against an isoproterenol-induced shedding of L-selectin. In contrast to CD62L, the surface density of the beta(2) integrin LFA-1 (CD11a) was higher on circulating lymphocytes(p < 0.001) (but not monocytes or lymphocytes) post-infusion. Isoproterenol also led to a mobilization of memory/activated CD8(+)CD29(high) T cells (p<0.01), but had no significant effect on the number of circulating CD8(+)CD45RA(+)CD62L(+) naive T cells. beta blockade with the non-specific antagonist propranolol eliminated these isoproterenol-induced effects. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:137 / 144
页数:8
相关论文
共 33 条
[1]   Catecholamine-induced leukocytosis: Early observations, current research, and future directions [J].
Benschop, RJ ;
RodriguezFeuerhahn, M ;
Schedlowski, M .
BRAIN BEHAVIOR AND IMMUNITY, 1996, 10 (02) :77-91
[2]   Adrenergic control of natural killer cell circulation and adhesion [J].
Benschop, RJ ;
Schedlowski, M ;
Wienecke, H ;
Jacobs, R ;
Schmidt, RE .
BRAIN BEHAVIOR AND IMMUNITY, 1997, 11 (04) :321-332
[3]  
BEVILACQUA MP, 1993, ANNU REV IMMUNOL, V77, P7657
[4]   Catecholamines decrease lymphocyte adhesion to cytokine-activated endothelial cells [J].
Carlson, SL ;
Beiting, DJ ;
Kiani, CA ;
Abell, KM ;
McGillis, JP .
BRAIN BEHAVIOR AND IMMUNITY, 1996, 10 (01) :55-67
[5]   Acute stress enhances while chronic stress suppresses cell-mediated immunity in vivo: A potential role for leukocyte trafficking [J].
Dhabhar, FS ;
McEwen, BS .
BRAIN BEHAVIOR AND IMMUNITY, 1997, 11 (04) :286-306
[6]   CIRCULATING SELECTIN-TYPE AND IMMUNOGLOBULIN-TYPE ADHESION MOLECULES IN ACUTE ISCHEMIC STROKE [J].
FASSBENDER, K ;
MOSSNER, R ;
MOTSCH, L ;
KISCHKA, U ;
GRAU, A ;
HENNERICI, M .
STROKE, 1995, 26 (08) :1361-1364
[7]  
Frey M, 1998, J IMMUNOL, V161, P400
[8]   Phenotypic and functional separation of memory and effector human CD8(+) T cells [J].
Hamann, D ;
Baars, P ;
Rep, MHG ;
Hooibrink, B ;
KerkhofGarde, SR ;
Klein, MR ;
vanLier, RAW .
JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 186 (09) :1407-1418
[9]   Effects of exercise on circulating vascular adhesion molecules in healthy men [J].
Jilma, B ;
Eichler, HG ;
Stohlawetz, P ;
Dirnberger, E ;
Kapiotis, S ;
Wagner, OF ;
Schutz, W ;
Krejcy, K .
IMMUNOBIOLOGY, 1997, 197 (05) :505-512
[10]   Moderate exercise leads to decreased expression of beta 1 and beta 2 integrins on leucocytes [J].
Jordan, J ;
Beneke, R ;
Hutler, M ;
Veith, A ;
Haller, H ;
Luft, FC .
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY AND OCCUPATIONAL PHYSIOLOGY, 1997, 76 (02) :192-194