Follicular Helper T Cells Promote Liver Pathology in Mice during Schistosoma japonicum Infection

被引：52

作者：

Chen, Xiaojun ^{[1
]}

Yang, Xiaowei ^{[1
]}

Li, Yong ^{[1
]}

Zhu, Jifeng ^{[1
]}

Zhou, Sha ^{[1
]}

Xu, Zhipeng ^{[1
]}

He, Lei ^{[1
,2
]}

Xue, Xue ^{[1
]}

Zhang, Weiwei ^{[1
]}

Dong, Xiaoxiao ^{[1
]}

Wu, Henry ^{[3
]}

Li, Carrie J. ^{[4
]}

Hsu, Hsiang-Ting ^{[1
]}

Kong, Wenjun ^{[1
]}

Liu, Feng ^{[1
]}

Tripathi, Prem B. ^{[4
]}

Yu, Michelle S. ^{[4
]}

Chang, Jason ^{[5
]}

Zhou, Liang ^{[2
]}

Su, Chuan ^{[1
]}

机构：

[1] Nanjing Med Univ, Dept Pathogen Biol & Immunol, Jiangsu Key Lab Pathogen Biol, Nanjing, Jiangsu, Peoples R China

[2] Northwestern Univ, Dept Pathol, Dept Microbiol & Immunol, Feinberg Sch Med, Chicago, IL 60611 USA

[3] Childrens Hosp Los Angeles, Dept Pediat, Los Angeles, CA 90027 USA

[4] Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USA

[5] Kaiser LAMC, Dept Gen Surg, Los Angeles, CA USA

来源：

PLOS PATHOGENS | 2014年 / 10卷 / 05期

基金：

中国国家自然科学基金;

关键词：

COMMON VARIABLE IMMUNODEFICIENCY; SYSTEMIC-LUPUS-ERYTHEMATOSUS; ANTIGEN-PRESENTING CELLS; B-CELL; IN-VIVO; PERITONEAL-MACROPHAGES; TH2; CELLS; INFLAMMATORY MACROPHAGE; INDUCIBLE COSTIMULATOR; GRANULOMA-FORMATION;

D O I：

10.1371/journal.ppat.1004097

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Following Schistosoma japonicum (S. japonicum) infection, granulomatous responses are induced by parasite eggs trapped in host organs, particular in the liver, during the acute stage of disease. While excessive liver granulomatous responses can lead to more severe fibrosis and circulatory impairment in chronically infected host. However, the exact mechanism of hepatic granuloma formation has remained obscure. In this study, we for the first time showed that follicular helper T (Tfh) cells are recruited to the liver to upregulate hepatic granuloma formation and liver injury in S. japonicum-infected mice, and identified a novel function of macrophages in Tfh cell induction. In addition, our results showed that the generation of Tfh cells driven by macrophages is dependent on cell-cell contact and the level of inducible costimulator ligand (ICOSL) on macrophages which is regulated by CD40-CD40L signaling. Our findings uncovered a previously unappreciated role for Tfh cells in liver pathology caused by S. japonicum infection in mice.

引用

页数：14

共 77 条

[1]

Dysregulated Generation of Follicular Helper T Cells in the Spleen Triggers Fatal Autoimmune Hepatitis in Mice [J].