The therapeutic effect of a combination of cofpropamine, a caffeine derivative, and cyclophosphamide on the development of adjuvant arthritis of rats and collagen arthritis of mice

被引：4

作者：

Kroger, H

Klosa, J

Gratz, R

Dietrich, A

Ehrlich, W

Wild, A

机构：

[1] ROBERT KOC INST, D-13353 BERLIN, GERMANY

[2] E MERCK AG, D-6100 DARMSTADT, GERMANY

来源：

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1996年 / 27卷 / 07期

关键词：

cyclophosphamide; cofpropamine; adjuvant arthritis; collagen arthritis;

D O I：

10.1016/S0306-3623(96)00069-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Cofpropamine(Cofa), a caffeine derivative that inhibits polyadenoribosylation, enhances the therapeutic effect of cyclophosphamide (CPA) in two animal models of arthritis. 2. The development of adjuvant arthritis of rats is reduced by treatment with 2 x 50 mg/kg IP CPA and 2 x 50 mg/kg IP Cofa. 3. The development of collagen arthritis in mice is prevented by treatment with 12.5 mg/kg IP CPA and 150 mg/kg IP Cofa three times per week. Copyright (C) 1996 Elsevier Science Inc.

引用

页码：1215 / 1218

页数：4

共 24 条

[1] CHEMOTHERAPEUTIC ACTION OF A CYCLIC NITROGEN MUSTARD PHOSPHAMIDE ESTER (B 518-ASTA) IN EXPERIMENTAL TUMOURS OF THE RAT [J].